RhoA-Dependent Phosphorylation and Relocalization of ERM Proteins into Apical Membrane/Actin Protrusions in Fibroblasts

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

The role of RhoA in tissue polarity and Frizzled signalling

1997 • 558 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

1993 • 426 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.

1995 • 422 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family.

1994 • 395 citations

Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor.

1989 • 385 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

F-actin binding site masked by the intramolecular association of vinculin head and tail domains

1995 • 371 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

Ezrin Is an Effector of Hepatocyte Growth Factor–mediated Migration and Morphogenesis in Epithelial Cells

1997 • 317 citations

ERM proteins: head-to-tail regulation of actin-plasma membrane interaction

1997 • 312 citations

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1997 • 309 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells.

1983 • 294 citations

Rho: a connection between membrane receptor signalling and the cytoskeleton

1996 • 271 citations

The rho gene product expressed in E. Coli is a substrate of botulinum ADP-ribosyltransferase C3

1989 • 252 citations

Moesin Interacts with the Cytoplasmic Region of Intercellular Adhesion Molecule-3 and Is Redistributed to the Uropod of T Lymphocytes during Cell Polarization

1997 • 238 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.

1996 • 215 citations

Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

1995 • 208 citations

Phosphorylation of Threonine 558 in the Carboxyl-terminal Actin-binding Domain of Moesin by Thrombin Activation of Human Platelets

1995 • 205 citations

The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.

1997 • 202 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

Identification of a phosphatidylinositol‐4,5‐bisphosphate‐binding domain in the N‐terminal region of ezrin

1995 • 198 citations

The PRK2 Kinase Is a Potential Effector Target of both Rho and Rac GTPases and Regulates Actin Cytoskeletal Organization

1997 • 195 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli.

1991 • 182 citations

The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein.

1986 • 173 citations

Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes.

1995 • 169 citations

Subcellular Localization of Moesin in Dynamic Filopodia, Retraction Fibers, and Other Structures Involved in Substrate Exploration, Attachment, and Cell-Cell Contacts

1995 • 147 citations

Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable

1993 • 135 citations

Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain.

1995 • 135 citations

Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation

1996 • 113 citations

Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury.

1995 • 107 citations

Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains.

1995 • 106 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI)

1994 • 100 citations

Interdomain Interactions of Radixin in Vitro

1995 • 93 citations

The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.

1993 • 90 citations

Characterization of an 80-kDa phosphoprotein involved in parietal cell stimulation

1989 • 80 citations

Pleckstrin Associates with Plasma Membranes and Induces the Formation of Membrane Projections: Requirements for Phosphorylation and the NH2-terminal PH Domain

1997 • 73 citations

Analysis of a cortical cytoskeletal structure: a role for ezrin-radixin-moesin (ERM proteins) in the marginal band of chicken erythrocytes

1994 • 51 citations

Cells in culture from rabbit medullary thick ascending limb of Henle's loop

1989 • 46 citations

Involvement of rho p21 and Its Inhibitory GDP/GTP Exchange Protein (rho GDI) in Cell Motility

1993 • 46 citations

Cytovillin and other microvillar proteins of human choriocarcinoma cells

1989 • 28 citations