A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

1996 • 1,127 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

1997 • 582 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

PDZ Proteins Organize Synaptic Signaling Pathways

1998 • 474 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

cAMP-mediated inhibition of the epithelial brush border Na ⁺ /H ⁺ exchanger, NHE3, requires an associated regulatory protein

1997 • 426 citations

A C-terminal motif found in the β ₂ -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na ⁺ /H ⁺ exchanger regulatory factor family of PDZ proteins

1998 • 406 citations

The Actin Cytoskeleton Is Required for Receptor-mediated Endocytosis in Mammalian Cells

1997 • 394 citations

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.

1995 • 344 citations

Synergistic Regulation of β₂-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization

1997 • 231 citations

Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor

1996 • 230 citations

Molecular mechanisms of G protein-coupled receptor desensitization and resensitization

1998 • 219 citations

Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization

1994 • 196 citations

The Carboxyl-terminal Region of EBP50 Binds to a Site in the Amino-terminal Domain of Ezrin That Is Masked in the Dormant Molecule

1998 • 194 citations

Mechanisms of β-Adrenergic Receptor Desensitization and Resensitization

1997 • 193 citations

Actin filaments facilitate two steps of endocytosis

1996 • 187 citations

Rhodopsin Phosphorylation and Dephosphorylation in Vivo

1995 • 176 citations

Regulated Endocytosis of G-protein-coupled Receptors by a Biochemically and Functionally Distinct Subpopulation of Clathrin-coated Pits

1998 • 136 citations

Desensitization of β2-Adrenergic Receptors with Mutations of the Proposed G Protein-coupled Receptor Kinase Phosphorylation Sites

1998 • 76 citations

A Novel Interaction between Adrenergic Receptors and the α-Subunit of Eukaryotic Initiation Factor 2B

1997 • 74 citations