Spatial Sensing in Fibroblasts Mediated by 3′ Phosphoinositides

Wound Healing--Aiming for Perfect Skin Regeneration

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Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

A Cell's Sense of Direction

1999 • 884 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

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Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

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Platelet-derived growth factor in chemotactic for fibroblasts.

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1998 • 733 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

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G Protein Signaling Events Are Activated at the Leading Edge of Chemotactic Cells

1998 • 626 citations

Photobleaching recovery and anisotropy decay of green fluorescent protein GFP-S65T in solution and cells: cytoplasmic viscosity probed by green fluorescent protein translational and rotational diffusion

1997 • 609 citations

Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.

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Platelet-derived growth factor receptor signals.

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PIP2 and PIP3

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PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

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Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

1999 • 444 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrix

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Signal transduction and actin filament organization

1996 • 309 citations

Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction

1999 • 288 citations

Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway

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Calpain Regulates Actin Remodeling during Cell Spreading

1998 • 264 citations

Lateral Transport of a Lipid Probe and Labeled Proteins on a Cell Membrane

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Extracellular matrix alters PDGF regulation of fibroblast integrins.

1996 • 225 citations

Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

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A stochastic model for leukocyte random motility and chemotaxis based on receptor binding fluctuations

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Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement

1996 • 195 citations

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo

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Imaging Constitutive Exocytosis with Total Internal Reflection Fluorescence Microscopy

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Patterns of elevated free calcium and calmodulin activation in living cells

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The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients

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Growth Factors And Wound Healing: Platelet-Derived Growth Factor As A Model Cytokine

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The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients

2000 • 153 citations

Fusion of Constitutive Membrane Traffic with the Cell Surface Observed by Evanescent Wave Microscopy

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A versatile microporation technique for the transfection of cultured CNS neurons

1999 • 139 citations

Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras Activity

1996 • 133 citations

Application of total internal reflection fluorescence microscopy to study cell adhesion to biomaterials

1998 • 119 citations

Membrane Interactions of a Constitutively Active GFP-Ki-Ras 4B and Their Role in Signaling

1999 • 117 citations

Cytosolic Free Calcium and the Cytoskeleton in the Control of Leukocyte Chemotaxis

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Physical modulation of intracellular signaling processes by locational regulation

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Total internal reflection fluorescence: applications in cellular biophysics

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Fluorescent tags of protein function in living cells

2000 • 19 citations