Ras-like GTPases

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Ras effectors

1996 • 445 citations

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

1995 • 424 citations

Integrin Activation by R-ras

1996 • 414 citations

Rapid Ca2+-mediated activation of Rap1 in human platelets

1997 • 401 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY

1995 • 361 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

1996 • 328 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.

1994 • 294 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins

1989 • 258 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

1991 • 245 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

Evidence for a Ras/Ral signaling cascade

1996 • 214 citations

Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

1994 • 207 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.

1993 • 174 citations

Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex

1994 • 167 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.

1993 • 159 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

Activation of Brain B-Raf Protein Kinase by Rap1B Small GTP-binding Protein

1996 • 151 citations

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

1995 • 142 citations

A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

1989 • 141 citations

Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras Activity

1996 • 133 citations

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

1997 • 131 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

Cloning and Characterization of Ras-GRF2, a Novel Guanine Nucleotide Exchange Factor for Ras

1997 • 131 citations

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex.

1991 • 128 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

The role of p21ras in receptor tyrosine kinase signalling

1994 • 114 citations

R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells.

1994 • 112 citations

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.

1991 • 110 citations

Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation

1995 • 109 citations

Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

1992 • 106 citations

Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.

1991 • 102 citations

Aberrant Function of the Ras-Related Protein TC21/R-Ras2 Triggers Malignant Transformation

1994 • 98 citations

Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.

1994 • 96 citations

Molecular Cloning of a Novel Mitogen-Inducible Nuclear Protein with a Ran GTPase-Activating Domain That Affects Cell Cycle Progression

1995 • 93 citations

Rap1-b is phosphorylated by protein kinase a in intact human platelets

1990 • 90 citations

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning.

1994 • 89 citations

Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.

1994 • 88 citations

Rheb Interacts with Raf-1 Kinase and May Function To Integrate Growth Factor- and Protein Kinase A-Dependent Signals

1997 • 87 citations

Regulation of tetradecanoyl phorbol acetate-induced responses in NIH 3T3 cells by GAP, the GTPase-activating protein associated with p21c-ras.

1992 • 84 citations

Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559

1992 • 78 citations

Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes.

1994 • 78 citations

RalGDS Functions in Ras- and cAMP-mediated Growth Stimulation

1997 • 72 citations

A Novel GTPase-activating Protein for R-Ras

1995 • 70 citations

R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation.

1994 • 65 citations

Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator

1997 • 63 citations

Characterization of Ral GDP Dissociation Stimulator-like (RGL) Activities to Regulate c-fosPromoter and the GDP/GTP Exchange of Ral

1997 • 63 citations

TC21 Causes Transformation by Raf-Independent Signaling Pathways

1996 • 62 citations

The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner

1994 • 62 citations

A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog ofrheb

1995 • 60 citations

Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals.

1995 • 58 citations

Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis.

1992 • 57 citations

R-Ras is regulated by activators and effectors distinct from those that control Ras function

1997 • 55 citations

Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

1994 • 55 citations

A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line.

1995 • 47 citations

Ultrastructural localization of the small GTP‐binding protein Rap 1 in human platelets and megakaryocytes

1994 • 42 citations

p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus.

1996 • 41 citations

GTP-Binding Proteins: Structures, interactions and relationships

1994 • 37 citations

Effects of the ras‐related rap2 protein on cellular proliferation

1991 • 33 citations

Localization of rap1 and rap2 proteins in the gelatinase‐containing granules of human neutrophils

1993 • 33 citations

The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor.

1996 • 30 citations

Incorporation of Rap 1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium.

1994 • 28 citations

Glycoprotein IIb-IIIa and the translocation of Rap2B to the platelet cytoskeleton.

1994 • 25 citations

The Rap1A Protein Enhances Protein Kinase C Activity in Vitro

1993 • 17 citations