Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

1994 • 407 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

1995 • 368 citations

A target for Src in mitosis

1994 • 361 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

The IRS-1 signaling system

1994 • 310 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

1995 • 288 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1992 • 271 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities

1995 • 220 citations

Peptide–Surface Association: The Case of PDZ and PTB Domains

1996 • 178 citations

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain.

1995 • 114 citations

Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn.

1995 • 111 citations

Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.

1994 • 109 citations

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.

1989 • 96 citations

Distinct Modes of Interaction of SHC and Insulin Receptor Substrate-1 with the Insulin Receptor NPEY Region via Non-SH2 Domains

1995 • 90 citations

Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins.

1993 • 90 citations

Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.

1991 • 88 citations

Characterization of a 60-kilodalton substrate of the insulin receptor kinase

1994 • 80 citations

The Nonreceptor Protein-Tyrosine Kinase CSK Complexes Directly with the GTPase-Activating Protein-Associated p62 Protein in Cells Expressing v-Src or Activated c-Src

1995 • 76 citations

The Human p62 cDNA Encodes Sam68 and Not the RasGAP-Associated p62 Protein

1996 • 74 citations

v-abl causes hematopoietic disease distinct from that caused by bcr-abl.

1991 • 46 citations

A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma.

1994 • 42 citations

Functional Role of GTPase-Activating Protein in Cell Transformation by pp6O^v-src

1993 • 29 citations

Activation of the colony-stimulating factor 1 receptor leads to the rapid tyrosine phosphorylation of GTPase-activating protein and activation of cellular p21ras.

1992 • 29 citations

Insulin-like growth factor-1 stimulation of cells induces formation of complexes containing phosphatidylinositol-3-kinase, guanosine triphosphatase-activating protein (GAP), and p62 GAP-associated protein.

1995 • 24 citations

Evidence for two distinct 60-kilodalton substrates of the SRC tyrosine kinase.

1994 • 23 citations

Ras complements the carboxyl terminus of v-Abl protein in lymphoid transformation

1996 • 18 citations

Functional role of GTPase-activating protein in cell transformation by pp60v-src.

1993 • 12 citations