The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

[10] Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast

1983 • 1,095 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins

1989 • 258 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

Complexes of polyoma virus medium T antigen and cellular proteins.

1985 • 223 citations

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

1987 • 216 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

Heterologous expression and characterization of the human R-ras gene product.

1987 • 73 citations

Purification of a factor capable of stimulating the guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular mass G proteins.

1990 • 73 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

Strategies for the identification of interacting proteins.

1993 • 60 citations

Reconstitution of the Raf-1-MEK-ERK Signal Transduction Pathway In Vitro

1993 • 51 citations

Effect of a Dominant Inhibitory Ha-ras Mutation on Mitogenic Signal Transduction in NIH 3T3 Cells

1990 • 42 citations

Chimeric proteins define variable and essential regions of Ha-ras-encoded protein.

1988 • 31 citations

Inhibition by Phospholipids of the Interaction between R-ras, Rho, and Their GTPase-Activating Proteins

1989 • 15 citations