Evidence for a Ras/Ral signaling cascade

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Integrin Activation by R-ras

1996 • 414 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

1996 • 328 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

Regulation of Ras-mediated signalling: more than one way to skin a cat

1995 • 292 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

The Ras superfamily of GTPases ¹

1996 • 269 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Identification of AF-6 and Canoe as Putative Targets for Ras

1996 • 207 citations

Rho-related proteins: actin cytoskeleton and cell cycle

1995 • 176 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.

1993 • 174 citations

A Human Protein Selected for Interference with Ras Function Interacts Directly with Ras and Competes with Raf1

1995 • 170 citations

Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA

1991 • 157 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells.

1994 • 112 citations

Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

The ras Superfamily of GTPases (1993)

2017 • 77 citations

Ra1 and Rab3a are major GTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaptosomal exocytosis

1993 • 70 citations

Regulation of Interaction of ras p21 with RalGDS and Raf-1 by Cyclic AMP-dependent Protein Kinase

1996 • 67 citations

R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation.

1994 • 65 citations

Characterization of a GTPase-activating protein for the Ras-related Ral protein

1991 • 63 citations

Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli.

1990 • 53 citations

The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies

1995 • 51 citations

Intracellular signalling mediated by protein-tyrosine kinases: Networking through phospholipid metabolism

1993 • 49 citations

Association of three small GTP‐binding proteins with cholinergic synaptic vesicles

1993 • 48 citations

Characterization of human platelet GTPase activating protein for the Ral GTP-binding protein

1996 • 22 citations

Co-expression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters plasma cholesterol distribution. Implications for the pathogenesis of type III hyperlipoproteinemia.

1994 • 6 citations