Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer

Translating the Histone Code

2001 • 9,488 citations

The language of covalent histone modifications

2000 • 8,260 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

COBRA: a sensitive and quantitative DNA methylation assay

1997 • 1,184 citations

The non-coding Air RNA is required for silencing autosomal imprinted genes

2002 • 1,040 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

2001 • 923 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Characterization of 21 newly established esophageal cancer cell lines

1992 • 490 citations

Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena

1999 • 480 citations

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1

2002 • 463 citations

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome

1999 • 405 citations

An imprinted gene p57KIP2 is mutated in Beckwith–Wiedemann syndrome

1996 • 390 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Genomic imprinting of p57KIP2, a cyclin–dependent kinase inhibitor, in mouse

1995 • 288 citations

Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1

2001 • 241 citations

LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids

1999 • 229 citations

Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome

2000 • 178 citations

Analysis of germline CDKN1C (p57^KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation

1999 • 178 citations

Increased tumour risk for BWS patients correlates with aberrant H19 and not KCNQ1OT1 methylation: occurrence of KCNQ1OT1 hypomethylation in familial cases of BWS

2001 • 175 citations

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57 ^KIP2 requires binding to proliferating cell nuclear antigen

1998 • 152 citations

Tumor-specific loss of 11p15.5 alleles in del11p13 Wilms tumor and in familial adrenocortical carcinoma.

1989 • 147 citations

Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome

2003 • 146 citations

Coding Mutations in p57 Are Present in Some Cases of Beckwith-Wiedemann Syndrome but Are Rare or Absent in Wilms Tumors

1997 • 140 citations

Genomic imprinting of human p57KIP2 and its reduced expression in Wilms' tumors

1996 • 139 citations

Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer

2004 • 137 citations

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer

2003 • 131 citations

Aberrant DNA methylation ofp57KIP2 gene in the promoter region in lymphoid malignancies of B-cell phenotype

2002 • 128 citations

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

2002 • 119 citations

Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer.

1994 • 115 citations

Hot-stop PCR: a simple and general assay for linear quantitation of allele ratios

2000 • 106 citations

Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas

2000 • 89 citations

Characterization of the human p57KIP2 gene: Alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis

1996 • 70 citations

Insulator and silencer sequences in the imprinted region of human chromosome 11p15.5

2003 • 65 citations

Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer

2000 • 54 citations

Loss of methylation at chromosome 11p15.5 is common in human adult tumors

2002 • 53 citations

Decreased expression of p57KIP2 mRNA in human bladder cancer

2000 • 53 citations

Bidirectional Silencing and DNA Methylation-sensitive Methylation-spreading Properties of the Kcnq1 Imprinting Control Region Map to the Same Regions

2003 • 42 citations

Loss of CpG Methylation Is Strongly Correlated with Loss of Histone H3 Lysine 9 Methylation at DMR-LIT1 in Patients with Beckwith-Wiedemann Syndrome

2003 • 39 citations