Role of DNA Methylation in the Regulation of Cell Function: Autoimmunity, Aging and Cancer

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

1990 • 546 citations

Genomic 5-methyldeoxycytidine decreases with age.

1987 • 504 citations

Methylation matters

2001 • 420 citations

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

1988 • 413 citations

Cloning, expression and chromosome locations of the human DNMT3 gene family

1999 • 412 citations

Rare Bases in Animal DNA

1970 • 375 citations

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

1993 • 350 citations

Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene

1997 • 327 citations

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

1995 • 304 citations

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

1996 • 254 citations

Decreased ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients

2001 • 253 citations

Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice.

1996 • 233 citations

Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.

1995 • 209 citations

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency

1993 • 204 citations

Regulation of DNA Methylation by the Ras Signaling Pathway

1995 • 190 citations

Phenotypic and functional similarities between 5‐azacytidine‐treated t cells and a t cell subset in patients with active systemic lupus erythematosus

1992 • 178 citations

The 5-Methylcytosine in DNA of Rats

1973 • 177 citations

5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence

2000 • 167 citations

The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents.

1973 • 167 citations

Effect of an inhibitor of DNA methylation on T cells. II. 5-azacytidine induces self-reactivity in antigen-specific T4+ cells

1986 • 149 citations

Procainamide inhibits DNA methyltransferase in a human T cell line.

1991 • 136 citations

Alterations in expression and methylation of specific gene in livers of rats fed a cancer promoting methyl-deficient diet

1991 • 125 citations

Lymphocyte function—associated antigen 1 overexpression and t cell autoreactivity

1994 • 124 citations

Mechanisms of drug‐induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo

1997 • 117 citations

Quantitative changes in T cell DNA methylation occur during differentiation and ageing

1990 • 91 citations

Role of the ras-MAPK Signaling Pathway in the DNA Methyltransferase Response to DNA Hypomethylation

1998 • 76 citations

Inhibition of Methylation by Adenosine in Adenosine Deaminase-Inhibited, Phytohemagglutinin-Stimulated Human Lymphocytes

1979 • 69 citations

Messenger RNA levels and methlation patterns of GAPDH and β-actin genes in rat liver, spleen and brain in relation to aging

1990 • 67 citations

Biological Significance of DNA Methylation in the Ageing Process

1993 • 67 citations

Age-associated changes in DNA methylation and mRNA level of the c-myc gene in spleen and liver of mice

1989 • 52 citations

Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity.

1997 • 45 citations

Unexpected Effects of a Heterozygous Dnmt1 Null Mutation on Age-Dependent DNA Hypomethylation and Autoimmunity

2001 • 43 citations

Methylation of repetitive DNA sequences in the brain during aging of the rat

1989 • 36 citations

Endogenous virus genomes become hypomethylated tissue—Specifically during aging process of C57BL mice

1989 • 33 citations

Quantitative Analysis of Lymphocyte CD1 la using Standardized Flow Cytometry

1993 • 32 citations

Analysis of human peripheral blood T cells and single-cell-derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome

1999 • 28 citations

Effects of ageing on folate metabolism in rats fed a long-term folate deficient diet.

1994 • 22 citations

DNA methylation in the regulation of T cell LFA-1 expression.

2000 • 21 citations

Age‐related increases in glial fibrillary acidic protein do not show proportionate changes in transcription rates or DNA methylation in the cerebral cortex and hippocampus of male rats

1994 • 20 citations

Retroviral gene expression as a possible biomarker of aging

1993 • 7 citations