Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

The non-coding Air RNA is required for silencing autosomal imprinted genes

2002 • 1,040 citations

Hematopoietic commitment during embryonic stem cell differentiation in culture.

1993 • 919 citations

Tsix, a gene antisense to Xist at the X-inactivation centre

1999 • 809 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Targeted Mutagenesis of Tsix Leads to Nonrandom X Inactivation

1999 • 509 citations

Role for DNA methylation in the control of cell type–specific maspin expression

2002 • 440 citations

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome

1999 • 405 citations

RNA: Guiding Gene Silencing

2001 • 375 citations

Position effect in human genetic disease

1998 • 374 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Human gene mutation

1993 • 316 citations

X Chromosome Inactivation Is Mediated by Xist RNA Stabilization

1997 • 294 citations

Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain

2001 • 288 citations

Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos

1979 • 284 citations

Long-range cis effects of ectopic X-inactivation centres on a mouse autosome

1997 • 268 citations

Stabilization of Xist RNA Mediates Initiation of X Chromosome Inactivation

1997 • 247 citations

Both X chromosomes function before visible X-chromosome inactivation in female mouse embryos

1978 • 219 citations

The Human Ubiquitin C Promoter Directs High Ubiquitous Expression of Transgenes in Mice

1996 • 203 citations

Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene.

1987 • 201 citations

An imprinted antisense transcript at the human GNAS1 locus

2000 • 165 citations

An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus

2000 • 160 citations

The relationship between chromosome structure and function at a human telomeric region

1997 • 149 citations

Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells

2001 • 145 citations

X–chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro

1978 • 133 citations

The molecular basis of alpha thalassemia in India. Its interaction with the sickle cell gene

1988 • 90 citations

The Pattern of Replication at a Human Telomeric Region (16p13.3): Its Relationship to Chromosome Structure and Gene Expression

1999 • 83 citations

The uniqueness of the imprinting mechanism

2000 • 83 citations

Understanding alpha globin gene expression: a step towards effective gene therapy.

1998 • 82 citations

Analysis of the human alpha-globin gene cluster in transgenic mice.

1993 • 65 citations

α-Thalassemia resulting from a negative chromosomal position effect

2000 • 58 citations

Transcription of tissue-specific genes in human preimplantation embryos

1997 • 46 citations

Effect of Phenylhydrazine-induced Hemolytic Anemia on Nuclear RNA Polymerase Activity of the Mouse Spleen

1973 • 42 citations

Characterization of a Widely Expressed Gene (LUC7-LIKE; LUC7L) Defining the Centromeric Boundary of the Human α-Globin Domain

2001 • 32 citations

Transcriptional activation of human adult alpha-globin genes by hypersensitive site-40 enhancer: function of nuclear factor-binding motifs occupied in erythroid cells.

1995 • 31 citations

Two different theta (θ) globin gene deletions observed among black newborn babies

1988 • 27 citations