Linking the epigenetic ‘language’ of covalent histone modifications to cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Translating the Histone Code

2001 • 9,488 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

2003 • 6,017 citations

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

2017 • 5,610 citations

The polycomb group protein EZH2 is involved in progression of prostate cancer

2002 • 2,600 citations

Hox genes in vertebrate development

1994 • 2,057 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

The power and the promise of DNA methylation markers

2003 • 1,544 citations

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

2001 • 1,480 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex

2003 • 1,264 citations

Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin

2003 • 1,199 citations

Histone and chromatin cross-talk

2003 • 1,187 citations

Histone acetylation and an epigenetic code

2000 • 1,164 citations

The Rb/E2F pathway: expanding roles and emerging paradigms

2000 • 1,125 citations

Controlling the double helix

2003 • 1,102 citations

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1999 • 1,091 citations

MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

2002 • 1,039 citations

Heterochromatin and Epigenetic Control of Gene Expression

2003 • 1,039 citations

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

2003 • 961 citations

Rb targets histone H3 methylation and HP1 to promoters

2001 • 892 citations

Stabilization of Chromatin Structure by PRC1, a Polycomb Complex

1999 • 794 citations

Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation

2000 • 782 citations

Histone H2A variants H2AX and H2AZ

2002 • 749 citations

Histone methylation versus histone acetylation: new insights into epigenetic regulation

2001 • 689 citations

Histone acetylation and deacetylation in yeast

2003 • 666 citations

Binary switches and modification cassettes in histone biology and beyond

2003 • 628 citations

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae

2001 • 590 citations

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

2002 • 582 citations

The genetics and genomics of cancer

2003 • 570 citations

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

2003 • 545 citations

Histone Methylation

2002 • 525 citations

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

2001 • 516 citations

Histone H2AX

2003 • 479 citations

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

2003 • 434 citations

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

2003 • 420 citations

Signaling Network Model of Chromatin

2002 • 399 citations

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

2003 • 362 citations

The role of DNA methylation in setting up chromatin structure during development

2003 • 351 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

Relevance of DNA methylation in the management of cancer

2003 • 321 citations

Histone H3 variants specify modes of chromatin assembly

2002 • 320 citations

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

2001 • 317 citations

Spectrum of hSNF5IINI1 Somatic Mutations in Human Cancer and Genotype-Phenotype Correlations

1999 • 308 citations

Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer.

2003 • 287 citations

Unsafe SETs: histone lysine methyltransferases and cancer

2002 • 286 citations

Gene-Specific Targeting of H3K9 Methylation Is Sufficient for Initiating Repression In Vivo

2002 • 263 citations

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

1998 • 245 citations

Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBFα/AML/PEBP2α) dependent activation of tissue-specific gene transcription

2000 • 236 citations

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

2003 • 199 citations

When the SWI/SNF complex remodels … the cell cycle

2001 • 196 citations

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

2003 • 194 citations

Linking the Rb and Polycomb Pathways

2001 • 188 citations

Role of protein methylation in chromatin remodeling and transcriptional regulation

2001 • 186 citations

ATP-dependent chromatin remodelling: SWI/SNF and Co. are on the job

1999 • 179 citations

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

2003 • 174 citations

Epigenomics and epigenetic therapy of cancer

2002 • 172 citations

The role of MLL in hematopoiesis and leukemia

2002 • 159 citations

Hypomethylation: One Side of a Larger Picture

2003 • 156 citations

Histone methyltransferases, diet nutrients and tumour suppressors

2002 • 148 citations

Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation in Human Cells

2001 • 142 citations

Structure of the SET domain histone lysine methyltransferase Clr4

2002 • 122 citations

The Nucleosome: A Powerful Regulator of Transcription

1998 • 109 citations

Targeting DNA methylation in cancer

2003 • 97 citations

The EZH2 polycomb transcriptional repressor—a marker or mover of metastatic prostate cancer?

2002 • 89 citations

Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner

2003 • 88 citations

The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex

2002 • 86 citations

Chromatin Modification, Leukaemia and Implications for Therapy

2002 • 47 citations

11q Deletions in Hematological Malignancies

2001 • 46 citations

Chromatin modifiers and tumor suppression

2001 • 36 citations

Transcriptional Control: An Activating Role for Arginine Methylation

2002 • 33 citations

Is medical genetics neglecting epigenetics?

2002 • 25 citations

Protective packaging for DNA

2003 • 20 citations

Genetic lesions and perturbation of chromatin architecture: A road to cell transformation

2001 • 19 citations

The Histone Minority Report

2003 • 16 citations

Increased ADP-ribosylation of histones in oral cancer

1993 • 14 citations

Epigenetics: SUPERMAN Dresses Up

2002 • 11 citations