A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

COBRA: a sensitive and quantitative DNA methylation assay

1997 • 1,184 citations

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

2000 • 1,024 citations

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

2000 • 960 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

2000 • 938 citations

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

1997 • 573 citations

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

2001 • 540 citations

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.

1999 • 475 citations

Imprinting in Prader–Willi and Angelman syndromes

1998 • 451 citations

Dnmt3a and Dnmt3b Are Transcriptional Repressors That Exhibit Unique Localization Properties to Heterochromatin

2001 • 440 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

1995 • 426 citations

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

1997 • 411 citations

Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.

1999 • 366 citations

SARPs: A family of secreted apoptosis-related proteins

1997 • 327 citations

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

2001 • 236 citations

Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population.

2001 • 223 citations

Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma

2001 • 207 citations

Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR.

1997 • 197 citations

WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

2001 • 175 citations

Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.

2000 • 170 citations

Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes

1999 • 122 citations

Characterization and glutamyl preferring carboxypeptidase function of prostate specific membrane antigen: A novel folate hydrolase

1997 • 121 citations

Loss of annexin II heavy and light chains in prostate cancer and its precursors.

2001 • 109 citations

Cloning and Characterization of a Secreted Frizzled-Related Protein that is Expressed by the Retinal Pigment Epithelium

1999 • 107 citations

Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy.

1999 • 87 citations

Characterization of Two Novel Protocadherins (PCDH8andPCDH9) Localized on Human Chromosome 13 and Mouse Chromosome 14

1998 • 77 citations

Where is APC going?

2001 • 54 citations

Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line

2000 • 44 citations

Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer

1998 • 28 citations

Primary structure of human, chicken, and Xenopus laevis p 11, a cellular ligand of the Src-kinase substrate, annexin II

1991 • 28 citations

A Low-Copy Repeat in Xq26 Represents a Novel Putatively Prenylated Protein Gene (CXX1) and Its Pseudogenes (DXS9914, DXS9915, and DXS9916)

1997 • 7 citations