Activation of the p53 DNA Damage Response Pathway after Inhibition of DNA Methyltransferase by 5-Aza-2′-deoxycytidine

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.

1994 • 667 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Low-Dose 5-Aza-2′-Deoxycytidine, a DNA Hypomethylating Agent, for the Treatment of High-Risk Myelodysplastic Syndrome: A Multicenter Phase II Study in Elderly Patients

2000 • 576 citations

Rapid colormetric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lymphokines

1984 • 561 citations

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines.

1998 • 376 citations

Pilot phase l-ll study on 5-aza-2??-deoxycytidine (Decitabine) in patients with metastatic lung cancer

1997 • 209 citations

Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells

1999 • 197 citations

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.

1999 • 191 citations

Chronic myelogenous leukemia in nonlymphoid blastic phase

1999 • 189 citations

Inhibition of tumorigenesis by a cytosine–DNA, methyltransferase, antisense oligodeoxynucleotide

1997 • 171 citations

The relationship of DNA methylation to cancer.

1996 • 157 citations

Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells

1997 • 146 citations

A Phase II Study of 5-AZA-2'Deoxycytidine (Decitabine) in Hormone Independent Metastatic (D2) Prostate Cancer

1998 • 139 citations

p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis.

2000 • 131 citations

Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis.

2000 • 117 citations

Down-regulation of Human DNA-(Cytosine-5) Methyltransferase Induces Cell Cycle Regulators p16 and p21WAF/Cip1 by Distinct Mechanisms

1999 • 113 citations

DNA Methyltransferase Inhibition Induces the Transcription of the Tumor Suppressor p21

2000 • 112 citations

Molecular, cellular and animal pharmacology of 5-AZA-2′-deoxycytidine

1985 • 89 citations

DNA methylation as a target for drug design.

1998 • 79 citations

Accumulating Active p53 in the Nucleus by Inhibition of Nuclear Export: A Novel Strategy to Promote the p53 Tumor Suppressor Function

1999 • 72 citations

Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53

1997 • 65 citations

The nuclear import of p53 is determined by the presence of a basic domain and its relative position to the nuclear localization signal

1999 • 56 citations

Decitabine (5-Aza-2'-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: preliminary observations.

1997 • 55 citations

Decitabine studies in chronic and acute myelogenous leukemia.

1997 • 40 citations

Molecular alterations in theTP53 gene of peripheral blood cells of patients with chronic myeloid leukemia

1998 • 23 citations

Proteolytic cleavage of p53: a model for the activation of p53 in response to DNA damage.

1997 • 19 citations

Detection of p53 gene mutations in human leukemia by PCR-SSCP analysis and direct nucleotide sequencing.

1998 • 2 citations