Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.

Cancer-epigenetics comes of age

1999 • 2,379 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.

1994 • 667 citations

How does DNA methylation repress transcription?

1997 • 532 citations

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines.

1998 • 376 citations

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.

1999 • 374 citations

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

1999 • 350 citations

Dependence of transcriptional repression on CpG methylation density.

1994 • 294 citations

hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents

1997 • 248 citations

Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.

1996 • 218 citations

Causes and consequences of microsatellite instability in endometrial carcinoma.

1999 • 217 citations

Pilot phase l-ll study on 5-aza-2??-deoxycytidine (Decitabine) in patients with metastatic lung cancer

1997 • 209 citations

In Vitro Reactivation of the FMR1 Gene Involved in Fragile X Syndrome

1998 • 192 citations

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

1999 • 181 citations

Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.

1997 • 179 citations

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

1999 • 159 citations

Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1

1999 • 119 citations

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes

1999 • 98 citations

Pharmacological approach for optimization of the dose schedule of 5-Aza-2’-deoxycytidine (Decitabine) for the therapy of leukemia

1997 • 72 citations

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.

1999 • 66 citations

Carcinogenicity and haemoglobin synthesis induction by cytidine analogues

1988 • 53 citations

2'-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation

1993 • 19 citations

PHASE-I AND PHASE-II TRIALS OF A LABORATORY-DERIVED SYNERGISTIC COMBINATION OF CISPLATIN AND 2'-DEOXY-5-AZACYTIDINE

1995 • 8 citations