Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

2000 • 1,024 citations

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

2000 • 960 citations

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

2000 • 938 citations

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

1981 • 910 citations

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

1999 • 806 citations

DNA methylation and gene expression

1991 • 685 citations

The DNA methylation paradox

1999 • 642 citations

How does DNA methylation repress transcription?

1997 • 532 citations

Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

2000 • 470 citations

Complex structure and regulation of the P16 (MTS1) locus.

1995 • 402 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

1999 • 321 citations

The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines.

1998 • 207 citations

Specific protection of methylated CpGs in mammalian nuclei

1989 • 195 citations

Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

2001 • 194 citations

MBD2‐MBD3 complex binds to hemi‐methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase

2000 • 145 citations

Susceptibility of Nonpromoter CpG Islands to De Novo Methylation in Normal and Neoplastic Cells

2001 • 144 citations

A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.

1995 • 135 citations

Genomic Alterations of the p19ARF Encoding Exons in T-Cell Acute Lymphoblastic Leukemia

1998 • 108 citations

p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro.

1996 • 99 citations

Effect of site-specific DNA methylation and mutagenesis on recognition by methylated DNA-binding protein from human placenta

1986 • 41 citations