An Osmosensing Signal Transduction Pathway in Mammalian Cells

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

PROKARYOTIC OSMOREGULATION: Genetics and Physiology

1991 • 779 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.

1993 • 211 citations

Activation of ion transport systems during cell volume regulation

1987 • 195 citations

Ionic Mechanisms of Cell Volume Regulation in Leukocytes

1990 • 154 citations

Heterogeneous expression of four MAP kinase isoforms in human tissues

1992 • 143 citations

c-fos may code for a common transcription factor within the hypothalamic neural circuits involved in osmoregulation

1992 • 107 citations

Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases.

1987 • 106 citations

Osmoregulation of Na(+)-inositol cotransporter activity and mRNA levels in brain glial cells

1992 • 89 citations

Response of human fibroblasts to hypertonic stress. Cell shrinkage is counteracted by an enhanced active transport of neutral amino acids.

1994 • 55 citations

Increase of c‐jun mRNA upon hypo‐osmotic cell swelling of rat hepatoma cells

1994 • 47 citations