Humoral markers of severity and prognosis of critical illness

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

Critical Care Medicine

1971 • 2,033 citations

Progress in Clinical and Biological Research

1979 • 1,317 citations

MIF as a glucocorticoid-induced modulator of cytokine production

1995 • 1,143 citations

Renal Function, Neurohormonal Activation, and Survival in Patients With Chronic Heart Failure

2000 • 1,021 citations

Plasma Brain Natriuretic Peptide as a Prognostic Indicator in Patients With Primary Pulmonary Hypertension

2000 • 881 citations

Serial blood lactate levels can predict the development of multiple organ failure following septic shock

1996 • 834 citations

Principles and Practice of Endocrinology and Metabolism.

1991 • 801 citations

Protection from septic shock by neutralization of macrophage migration inhibitory factor

2000 • 728 citations

Experimental and Clinical Studies on Lactate and Pyruvate as Indicators of the Severity of Acute Circulatory Failure (Shock)

1970 • 715 citations

LACTATE CLEARANCE AND SURVIVAL FOLLOWING INJURY

1993 • 702 citations

Endothelins

1995 • 682 citations

An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.

1996 • 670 citations

Plasma N-Terminal Pro–Brain Natriuretic Peptide and Adrenomedullin

1998 • 662 citations

Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit

2000 • 620 citations

Serial lactate determinations during circulatory shock

1983 • 570 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction

1995 • 479 citations

Ubiquitous Expression of the Calcitonin-I Gene in Multiple Tissues in Response to Sepsis¹

2001 • 445 citations

Plasma Leptin Levels Are Increased in Survivors of Acute Sepsis: Associated Loss of Diurnal Rhythm in Cortisol and Leptin Secretion

1998 • 393 citations

Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk

1996 • 342 citations

Plasma tumor necrosis factor and mortality in critically ill septic patients

1989 • 324 citations

Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis

1998 • 322 citations

Interleukin-8 in sepsis: relation to shock and inflammatory mediators

1992 • 313 citations

Elevation of circulating interleukin 6 after surgery: Factors influencing the serum level

1994 • 291 citations

Ubiquitous Expression of the Calcitonin-I Gene in Multiple Tissues in Response to Sepsis

2001 • 288 citations

Overproduction of Nitric Oxide in Cytokine-Mediated and Septic Shock

1992 • 271 citations

Determinants and importance of stress hyperglycaemia in non-diabetic patients with myocardial infarction.

1986 • 268 citations

An overview of mortality risk prediction in sepsis

1995 • 251 citations

Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study

2001 • 251 citations

Predictive Value of Nuclear Factor κB Activity and Plasma Cytokine Levels in Patients with Sepsis

2000 • 251 citations

Risk factors for coronary heart disease and acute-phase proteins. A population-based study

1999 • 240 citations

Prognostic value of plasma endothelin-1 in patients with chronic heart failure

1997 • 238 citations

Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone.

1995 • 227 citations

Elevated Plasma Endothelin-1 Concentrations Are Associated with the Severity of Illness in Patients with Sepsis

1991 • 227 citations

Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin

1994 • 219 citations

Prediction of outcome in intensive care patients using endocrine parameters

1995 • 218 citations

Changes in blood lymphocyte populations after multiple trauma

1999 • 212 citations

Relationship Between Admission Hyperglycemia and Neurologic Outcome of Severely Brain-Injured Patients

1989 • 207 citations

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

2000 • 206 citations

The role of mediators in the response to thermal injury

1992 • 196 citations

Leptin Is an Endogenous Protective Protein against the Toxicity Exerted by Tumor Necrosis Factor

1999 • 190 citations

Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock

1991 • 188 citations

High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock

2000 • 182 citations

Relationship of Plasma Leptin to Plasma Cytokines and Human Survivalin Sepsis and Septic Shock

1999 • 181 citations

Low lipid concentrations in critical illness

1996 • 180 citations

Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome

1994 • 180 citations

The Influence of Hyperglycemia and Diabetes Mellitus on Immediate and 3-Month Morbidity and Mortality After Acute Stroke

1990 • 178 citations

Prevalence and clinical implications of hypocalcemia in acutely III patients in a medical intensive care setting

1988 • 167 citations

Serum Calcitonin Precursors in Sepsis and Systemic Inflammation¹

1998 • 166 citations

Principles and practice of endocrinology and metabolism

1992 • 164 citations

Oxygen Delivery in Critically III Patients

1985 • 160 citations

Roles of secretory phospholipases A2 in inflammatory diseases and trauma

2000 • 158 citations

Confirmatory platelet-activating factor receptor antagonist trial in patients with severe Gram-negative bacterial sepsis

1998 • 154 citations

Posttraumatic Complications and Inflammatory Mediators

1986 • 147 citations

Elevated Plasma Concentrations of Interferon (IFN)–γ and the IFN‐γ–Inducing Cytokines Interleukin (IL)–18, IL‐12, and IL‐15 in Severe Melioidosis

1999 • 144 citations

Macrophage Migration Inhibitory Factor and Hypothalamo-Pituitary-Adrenal Function during Critical Illness

2001 • 144 citations

Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans

1992 • 141 citations

The Relationships between Plasma Substrates and Hormones and the Severity of Injury in 277 Recently Injured Patients

1979 • 140 citations

Elevated plasma levels of endothelin in patients with sepsis syndrome.

1991 • 137 citations

Evidence for endothelial cell activation/injury in heatstroke

1996 • 133 citations

Serum tumor necrosis factor levels in patients with infectious disease and septic shock.

1990 • 128 citations

Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit

1996 • 128 citations

Disordered calcium homeostasis of sepsis: association with calcitonin precursors

2000 • 126 citations

Development of postoperative insulin resistance is associated with the magnitude of operation.

1993 • 124 citations

Oversecretion of IL‐18 in haemophagocytic lymphohistiocytosis: a novel marker of disease activity

1999 • 118 citations

Prognostic value of serum cytokines in patients with congestive heart failure

2000 • 118 citations

Anaphylatoxin Generation in Multisystem Organ Failure

1984 • 115 citations

Leptin and Interleukin-6 in Sepsis

1998 • 113 citations

Blood Sugar and Insulin Response of Humans in Shock

1970 • 111 citations

Neurologic outcome and blood glucose levels during out‐of‐hospital cardiopulmonary resuscitation

1986 • 107 citations

Increased nuclear factor κB activation in critically ill patients who die

2000 • 107 citations

A Novel Acute-Phase Marker: Lipopolysaccharide Binding Protein (LBP)

1999 • 107 citations

Effects of Trauma and Sepsis on Soluble L-Selectin and Cell Surface Expression of L-Selectin and CD11b

1998 • 100 citations

Endocrine profiles for outcome prediction from the intensive care unit

1993 • 97 citations

Serum Calcitonin Precursors in Sepsis and Systemic Inflammation

1998 • 96 citations

Plasma brain natriuretic peptide — an independent predictor of cardiovascular mortality in acute heart failure

1999 • 94 citations

SCORING SYSTEMS AND BLOOD LACTATE CONCENTRATIONS IN RELATION TO THE DEVELOPMENT OF ADULT RESPIRATORY DISTRESS SYNDROME AND MULTIPLE ORGAN FAILURE IN SEVERELY TRAUMATIZED PATIENTS

1993 • 92 citations

The C-reactive protein to prealbumin ratio correlates with the severity of multiple organ dysfunction

1998 • 86 citations

Complement Activation in Relation to Capillary Leakage in Children with Septic Shock and Purpura

1998 • 86 citations

Circulating endothelin-1 and tumor necrosis factor-α: early predictors of mortality in patients with septic shock

2000 • 85 citations

Nitric Oxide Production Is Increased in Patients after Burn Injury

1996 • 80 citations

Soluble selectins and the systemic inflammatory response syndrome after successful cardiopulmonary resuscitation

2000 • 77 citations

Effects of Anti‐inflammatory Agents on Serum Levels of Calcitonin Precursors during Human Experimental Endotoxemia

2001 • 77 citations

Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes.

2000 • 76 citations

Circulating Leptin Levels during Acute Experimental Endotoxemia and Antiinflammatory Therapy in Humans

1998 • 71 citations

Correlation between serum IL-6 and CRP levels and severity of head injury in children

1999 • 71 citations

Leukocyte Responses to Injury

1993 • 71 citations

Systemic Inflammatory Response in Cardiac Allograft Vasculopathy : High-Sensitive C-Reactive Protein Is Associated With Progressive Luminal Obstruction

2000 • 69 citations

Soluble Cytokine Receptors and Receptor Antagonists Are Sequentially Released after Trauma

1995 • 69 citations

Ionized hypocalcemia in critically ill patients with sepsis.

1978 • 68 citations

Acta Paediatrica Japonica

1991 • 68 citations

RETRACTED: Do Plasma Levels of Circulating Soluble Adhesion Molecules Differ Between Surviving and Nonsurviving Critically III Patients?

1995 • 68 citations

Association of tumor necrosis factor-2 allele with plasma tumor necrosis factor-alpha levels and mortality from septic shock

2001 • 66 citations

Acute phase proteins, C-reactive protein and serum amyloid A protein, as prognostic markers in the elderly inpatient

1997 • 60 citations

Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome: Mortality prognostic study

2000 • 60 citations

Elevation of plasma adenosine levels may attenuate the severity of chronic heart failure.

1998 • 59 citations

Soluble Tumor Necrosis Factor Receptors are Elevated in Relation to Severity of Congestive Heart Failure

1997 • 59 citations

Ceramide concentrations in septic patients: A possible marker of multiple organ dysfunction syndrome

1999 • 58 citations

Detrimental Effects of a Nitric Oxide Synthase Inhibitor (N-ω-Nitro-L-Arginine-Methyl-Ester) in a Murine Sepsis Model

1995 • 58 citations

DECREASED ORGAN FAILURE IN PATIENTS WITH SEVERE SIRS AND SEPTIC SHOCK TREATED WITH THE PLATELET-ACTIVATING FACTOR ANTAGONIST TCV-309: A PROSPECTIVE, MULTICENTER, DOUBLE-BLIND, RANDOMIZED PHASE II TRIAL

2000 • 57 citations

Initial Serum Ferritin Levels in Patients with Multiple Trauma and the Subsequent Development of Acute Respiratory Distress Syndrome

1999 • 56 citations

Nephrology, dialysis and transplantation

1993 • 55 citations

Direct comparison between endothelin-1, N-terminal proatrial natriuretic factor, and brain natriuretic peptide as prognostic markers of survival in congestive heart failure

2000 • 55 citations

Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis

2000 • 55 citations

Increased preoperative C-reactive protein (CRP)-values without signs of an infection and complicated course after cardiopulmonary bypass (CPB) – operations

1998 • 55 citations

THE CO-ORDINATED CYTOKINE/HORMONE RESPONSE TO ACUTE INJURY INCORPORATES LEPTIN

2000 • 54 citations

INTERLEUKIN 12 LEVELS DURING THE INITIAL PHASE OF SEPTIC SHOCK WITH PURPURA IN CHILDREN: RELATION TO SEVERITY OF DISEASE

1997 • 50 citations

Patterns of Heat-Shock Protein 70 Biosynthesis Following Human Traumatic Brain Injury

1998 • 49 citations

Nitric oxide production is enhanced in patients with heat stroke

1999 • 48 citations

Increased plasma concentrations of brain natriuretic peptide in patients with acute lung injury

1997 • 48 citations

Leukocyte L-Selectin Is Up-Regulated after Mechanical Trauma in Adults

1998 • 48 citations

Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage

2000 • 48 citations

Production of platelet-activating factor in patients with sepsis-associated acute renal failure

1999 • 46 citations

Heat shock protein (HSP70) expression in septic patients

1997 • 45 citations

Interleukin 18 (IL-18) levels in patients with sepsis.

2000 • 45 citations

The bigger the burn, the greater the stress

1997 • 45 citations

Calcitonin Gene Family of Peptides

2002 • 45 citations

Prognostic importance of hyperglycaemia induced by stress after acute myocardial infarction.

1984 • 41 citations

Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release

1986 • 40 citations

Interleukin 1 receptor antagonist and E-selectin concentrations: A comparison in patients with severe acute pancreatitis and severe sepsis

1999 • 39 citations

Phospholipase A₂: Its Usefulness in Laboratory Diagnostics

1999 • 38 citations

Neutrophil activation after burn injury: contributions of the classic complement pathway and of endotoxin.

1987 • 36 citations

Hyperthermia Induces Heat-Shock Protein Expression, Reduces Pancreatic Injury, and Improves Survival in Necrotizing Pancreatitis

2000 • 36 citations

Plasma levels of TNF-alpha, endothelin-1 and thrombomodulin in patients with sepsis.

1994 • 36 citations

Leptin Levels in Protracted Critical Illness: Effects of Growth Hormone-Secretagogues and Thyrotropin-Releasing Hormone¹

1998 • 36 citations

Plasma levels of high-energy compounds compared with severity of illness in critically ill patients in the intensive care unit

1998 • 35 citations

Disease Severity Is Correlated with Plasma Clotting and Fibrinolytic and Kinin-Kallikrein Activity in Neonatal Respiratory Distress Syndrome

1997 • 34 citations

BLOOD GLUCOSE AND PROGNOSIS OF ACUTE STROKE

1988 • 34 citations

Enhanced urinary excretion of leukotriene E4 by patients with multiple trauma with or without adult respiratory distress syndrome

1991 • 32 citations

SOLUBLE FAS LEVELS CORRELATE WITH MULTIPLE ORGAN DYSFUNCTION SEVERITY, SURVIVAL AND NITRATE LEVELS, BUT NOT WITH CELLULAR APOPTOTIC MARKERS IN CRITICALLY ILL PATIENTS

2000 • 31 citations

Lipopolysaccharide binding protein in acute pancreatitis

2000 • 30 citations

Cysteinyl-leukotriene generation as a biomarker for survival in the critically ill

2000 • 30 citations

Cascade system activation in shock

1993 • 30 citations

INCREASED CONCENTRATIONS OF PLASMA IL-18 IN PATIENTS WITH HEPATIC DYSFUNCTION AFTER HEPATECTOMY

2000 • 29 citations

Lymphocyte activation after non-thermal trauma

2000 • 29 citations

L‐selectin in trauma patients: a marker for organ dysfunction and outcome?

1999 • 29 citations

Leptin Levels in Protracted Critical Illness: Effects of Growth Hormone-Secretagogues and Thyrotropin-Releasing Hormone

1998 • 28 citations

THE VALUE OF IMMUNE MODULATING PARAMETERS IN PREDICTING THE PROGRESSION FROM PERITONITIS TO SEPTIC SHOCK

2001 • 28 citations

Associations between atrial natriuretic peptides, echocardiographic findings and mortality in an elderly population sample

1997 • 27 citations

UNINTENDED IMMUNOMODULATION: PART I. EFFECTS OF COMMON CLINICAL CONDITIONS ON CYTOKINE BIOSYNTHESIS

2000 • 27 citations

N-terminal proatrial natriuretic peptide and prognosis in patients with heart failure and preserved systolic function

2000 • 26 citations

Burns. Infection and immunology.

1985 • 24 citations

Oxygen delivery in critically ill patients

1996 • 23 citations

Depressed Plasma Platelet- Activating Factor Acetylhydrolasein Pat ients Presenting with Acute Myocardial Infarction

1998 • 22 citations

Heat shock protein 70 messenger RNA reflects the severity of ischemia/hypoxia-reperfusion injury in the perfused rat liver

1997 • 22 citations

EARLY POSTTRAUMATIC INCREASE IN PRODUCTION OF NITRIC OXIDE IN HUMANS

1998 • 21 citations

‘Sepsis’ and multi-organ failure: predictors of poor outcome after hematopoietic stem cell transplantation in children

2000 • 21 citations

Endotoxin-induced hypocalcemia results in defective calcium mobilization in rats.

1988 • 20 citations

Re-establishment of homeostasis and the acute-phase proteins.

1997 • 19 citations

Heat shock response reduces mortality after severe experimental burns

2000 • 18 citations

MIF, a previously unrecognized pituitary hormone and macrophage cytokine, is a pivotal mediator in endotoxic shock.

1994 • 18 citations

Platelet-activating factor and cytokine interactions in shock

1989 • 16 citations

Prevalence and clinical implications of hypocalcemia in acutely ill patients in a medical intensive care setting

1988 • 14 citations

Heat stress is associated with decreased lactic acidemia in rat sepsis.

2000 • 14 citations

Nuclear factor kappaB activation in acute appendicitis: a molecular marker for extent of disease?

2000 • 14 citations

Evidence for a role of kallikrein-kinin system in patients with shock after blunt trauma

1998 • 12 citations

Plasma platelet‐activating factor levels in newborn infants with and without perinatal asphyxia: Is it an additional marker of perinatal asphyxia?

1998 • 10 citations

Infarct volume, neurological severity and PAF binding to platelets of patients with acute cerebral ischemic stroke

1999 • 9 citations

Experimental and clinical evidence of leukocyte activation in trauma and sepsis.

1994 • 9 citations

Release of tumor necrosis factor alpha and its soluble receptor p55 in clinical septic syndrome.

1997 • 2 citations

[The diagnostic value of changes in the kallikrein-kinin system indices in patients with acute pancreatitis].

1999 • 1 citations

Deleted Work

1955 • 0 citations