Circulating endothelin-1 and tumor necrosis factor-α: early predictors of mortality in patients with septic shock

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations

1997 • 400 citations

Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma

1997 • 357 citations

Elevated Plasma Endothelin-1 Concentrations Are Associated with the Severity of Illness in Patients with Sepsis

1991 • 227 citations

Elevated plasma levels of endothelin in patients with sepsis syndrome.

1991 • 137 citations

Cytokine Profile and Correlation to the APACHE III and MPM II Scores in Patients with Sepsis

1997 • 117 citations

Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock

1996 • 112 citations

Oxygen consumption in sepsis and septic shock

1991 • 99 citations

Soluble TNF binding proteins modulate the negative inotropic properties of TNF-alpha in vitro

1995 • 90 citations

Increased plasma concentrations of soluble tumor necrosis factor receptors in sepsis syndrome

1994 • 81 citations

Early prediction of outcome in score-identified, postcardiac surgical patients at high risk for sepsis, using soluble tumor necrosis factor receptor-p55 concentrations

1996 • 74 citations

Endothelin production in sepsis and the adult respiratory distress syndrome

1996 • 68 citations

Endothelin-1 and Blood Pressure After Inhibition of Nitric Oxide Synthesis in Human Septic Shock

1999 • 62 citations

Monocyte Tumor Necrosis Factor Receptor Levels as a Predictor of Risk in Human Sepsis

1996 • 49 citations

Pathophysiologic role of endothelin-1 in renal function in rats with endotoxin shock.

1994 • 48 citations

Cytokine production and its manipulation by vasoactive drugs.

1996 • 43 citations

Plasma levels of TNF-alpha, endothelin-1 and thrombomodulin in patients with sepsis.

1994 • 36 citations

Alterations in transcriptional regulation of proinflammatory and immunoregulatory cytokine expression by hemorrhage, injury, and critical illness.

1996 • 26 citations

Temporal physiologic patterns of shock and circulatory dysfunction based on early descriptions by invasive and noninvasive monitoring.

1996 • 12 citations