Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference

1992 • 4,689 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome

1993 • 1,068 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1994 • 920 citations

Serum Cytokine Levels in Human Septic Shock

1993 • 882 citations

Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria

1989 • 852 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Cytokine Serum Level During Severe Sepsis in Human IL-6 as a Marker of Severity

1992 • 799 citations

Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines.

1992 • 737 citations

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

1994 • 714 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

1993 • 427 citations

Role of tumor necrosis factor-α in disease states and inflammation

1993 • 415 citations

Anticytokine Strategies in the Treatment of the Systemic Inflammatory Response Syndrome

1993 • 397 citations

Interleukin-8 in sepsis: relation to shock and inflammatory mediators

1992 • 313 citations

Tumor necrosis factor in the pathogenesis of infectious diseases

1993 • 239 citations

Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin

1994 • 219 citations

Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality.

1990 • 217 citations

Prolonged elevation of interleukin-8 and interleukin-6 concentrations in plasma and of leukocyte interleukin-8 mRNA levels during septicemic and localized Pseudomonas pseudomallei infection

1992 • 161 citations

Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6.

1991 • 154 citations

Serum tumor necrosis factor levels in patients with infectious disease and septic shock.

1990 • 128 citations

A Critical Evaluation of New Agents for the Treatment of Sepsis

1991 • 109 citations

LOCAL PRODUCTION OF INTERLEUKIN-8 IS ASSOCIATED WITH NOSOCOMIAL PNEUMONIA

1992 • 70 citations

Sandwich Elisa for Detection of Picogram Quantities of Interleukin-8

1991 • 68 citations

SERUM TUMOR NECROSIS FACTOR-ALPHA PROFILE IN TRAUMA PATIENTS

1993 • 63 citations

Tumor necrosis factor and the therapeutic potential of anti-tumor necrosis factor antibodies

1993 • 39 citations