Endothelins

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

1994 • 1,002 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

1994 • 886 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Characterization of a coronary vasoconstrictor produced by cultured endothelial cells

1985 • 616 citations

Endothelin in human congestive heart failure.

1994 • 598 citations

Contribution of endogenous generation of endothelin-1 to basal vascular tone

1994 • 588 citations

Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes.

1993 • 576 citations

Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells.

1993 • 576 citations

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

1993 • 529 citations

Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.

1994 • 521 citations

The Human Preproendothelin-1 Gene

1989 • 441 citations

Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction.

1994 • 404 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Role of endothelin in cyclosporine-induced glomerular dysfunction

1990 • 368 citations

Endothelins: multifunctional renal peptides.

1993 • 306 citations

Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis

1993 • 284 citations

Cyclosporine-induced synthesis of endothelin by cultured human endothelial cells.

1991 • 248 citations

Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src

1993 • 230 citations

Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

1991 • 226 citations

Increased plasma endothelin-1 in acute ischemic stroke.

1992 • 221 citations

The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage

1992 • 217 citations

Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles.

1993 • 216 citations

Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells.

1992 • 207 citations

A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670.

1994 • 201 citations

Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction

1991 • 194 citations

Termination of endothelin signaling: Role of nitric oxide

1994 • 193 citations

Endothelin has biological actions at pathophysiological concentrations.

1991 • 191 citations

Endothelin receptor antagonism is protective in in vivo acute cyclosporine toxicity

1992 • 176 citations

Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence.

1990 • 170 citations

Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells.

1994 • 162 citations

Hypertension Associated with Endothelin-Secreting Malignant Hemangioendothelioma

1991 • 158 citations

Effect of carbon dioxide and oxygen on endothelin production by cultured porcine cerebral endothelial cells.

1991 • 158 citations

The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion

1993 • 153 citations

Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents

1994 • 152 citations

Endothelin-3 is a novel neuropeptide: Isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain

1989 • 142 citations

Specific Binding of Endothelin on Human Bronchial Smooth Muscle Cells in Culture and Secretion of Endothelin-like Material from Bronchial Epithelial Cells

1990 • 140 citations

Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells.

1991 • 136 citations

Plasma big endothelin-1 concentrations in congestive heart failure patients with or without systemic hypertension

1993 • 127 citations

Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.

1994 • 120 citations

Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. Mediation through the C receptor.

1992 • 116 citations

Endothelin release during ischaemia and reperfusion of isolated perfused rat hearts

1992 • 103 citations

Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus

1989 • 94 citations

Immunocytochemical localization of endothelin in cultured bovine endothelial cells

1990 • 94 citations

A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells.

1990 • 89 citations

Endothelin: A potent vasoconstrictor associated with coronary vasospasm

1989 • 83 citations

Endothelin inhibits presynaptic adrenergic neurotransmission in rat mesenteric artery

1989 • 81 citations

Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture

1991 • 78 citations

Endothelin-1 Releases Prostacyclin and Inhibits ex vivo Platelet Aggregation in the Anesthetized Rabbit

1989 • 75 citations

Nonpeptide endothelin antagonist. Cerebrovascular characterization and effects on delayed cerebral vasospasm.

1994 • 67 citations

Endothelin-1 release from lamb ductus arteriosus; relevance to postnatal closure of the vessel

1991 • 64 citations

Endothelin Enhances Adrenocorticotropin-Stimulated Aldosterone Release from Cultured Bovine Adrenal Cells*

1990 • 63 citations

Na(+)-K(+)-Cl- cotransporter of brain capillary endothelial cells. Properties and regulation by endothelins, hyperosmolar solutions, calyculin A, and interleukin-1.

1994 • 62 citations

Endothelin: A Potent Stimulus of Atrial Natriuretic Peptide Secretion by Superfused Rat Atria and Its Dependency on Calcium*

1990 • 54 citations

Vascular responses to endothelin-1 in atherosclerotic primates.

1990 • 51 citations

High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells.

1994 • 49 citations

Insulin stimulates endothelin binding and action on cultured vascular smooth muscle cells

1993 • 42 citations

Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia

1991 • 40 citations

Hemodynamic and tubular effects of endothelin and thromboxane in the isolated perfused rat kidney

1989 • 33 citations

Endothelin Receptors on Cultured Fetal Rat Diencephalic Glia

1992 • 30 citations

Antiaggregatory and Hypotensive Effects of Endothelin-1 in Beagle Dogs

1991 • 30 citations

Role of thromboxane receptor activation in the bronchospastic response to endothelin

1990 • 30 citations

Vasoconstrictive responses elicited by endothelin in bovine cerebral arteries

1992 • 16 citations

Atrial natriuretic peptide and endothelin: Interactions in the central nervous system and the periphery

1991 • 8 citations

Endothelin-1 and Big Endothelin Cause Subarachnoid Hemorrhage in the Anesthetized Rabbit

1991 • 7 citations