Interleukin-8 in sepsis: relation to shock and inflammatory mediators

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.

1989 • 1,993 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Septic Shock in Humans

1990 • 1,170 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

1987 • 983 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8

1991 • 813 citations

Increased plasma levels of interleukin-6 in sepsis [see comments]

1989 • 813 citations

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

1990 • 796 citations

Catalyzed reporter deposition, a novel method of signal amplification application to immunoassays

1989 • 765 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects

1990 • 681 citations

A novel neutrophil-activating factor produced by human mononuclear phagocytes.

1988 • 655 citations

The effects of bacterial endotoxins on host mediation systems. A review.

1978 • 648 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity.

1987 • 542 citations

Promotion and Subsequent Inhibition of Plasminogen Activation after Administration of Intravenous Endotoxin to Normal Subjects

1989 • 487 citations

Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions

1989 • 459 citations

Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents.

1991 • 452 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.

1987 • 425 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity.

1988 • 318 citations

IL-8 in septic shock, endotoxemia, and after IL-1 administration.

1991 • 313 citations

A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice.

1991 • 298 citations

Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation.

1991 • 262 citations

The role of IFN-gamma in the pathology of experimental endotoxemia.

1990 • 257 citations

Sensitive ELISA for interleukin-6

1991 • 246 citations

Fibrinolytic response to tumor necrosis factor in healthy subjects.

1991 • 242 citations

Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis

1989 • 218 citations

Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice.

1990 • 216 citations

In vivo inflammatory activity of neutrophil-activating factor, a novel chemotactic peptide derived from human monocytes.

1989 • 198 citations

Quantification of plasma factor XIIa-Cl(-)-inhibitor and kallikrein-Cl(- )-inhibitor complexes in sepsis

1988 • 196 citations

Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis.

1992 • 190 citations

The monocyte-derived neutrophil activating peptide (NAP/interleukin 8) stimulates human neutrophil arachidonate-5-lipoxygenase, but not the release of cellular arachidonate.

1989 • 172 citations

Proteolytic inactivation of plasma C1- inhibitor in sepsis.

1989 • 141 citations

Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants.

1990 • 138 citations

Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins

1989 • 137 citations

Novel neutrophil-stimulating peptides

1989 • 129 citations

Plasma Neutrophil-Activating Peptide-1/lnterleukin-8 and Neutrophil Elastase in a Primate Bacteremia Model

1991 • 99 citations

The sequential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1.

1991 • 94 citations

Prevention of pulmonary injury in isolated perfused rat lungs by activated human neutrophils preincubated with anti-Mo1 monoclonal antibody.

1987 • 93 citations

Analysis of human IL-6 mutants expressed in Escherichia coli. Biologic activities are not affected by deletion of amino acids 1-28.

1989 • 91 citations

A C1-inhibitor-complex assay (INCA): a method to detect C1 activation in vitro and in vivo.

1981 • 73 citations

Detection of Activation of the Contact System of Coagulation In Vitro and In Vivo: Quantitation of Activated Hageman Factor-C1-Inhibitor and Kallikrein-C1-Inhibitor Complexes by Specific Radioimmunoassays

1987 • 54 citations

Pulmonary edema induced by phagocytosing neutrophils. Protective effect of monoclonal antibody against phagocyte CD18 integrin.

1990 • 53 citations

Interleukin-8 and related molecules

1991 • 51 citations

Quantification of Functional and Inactivated α2-Macroglobulin in Sepsis

1991 • 46 citations

A Peptide from Alveolar Macrophages That Releases Neutrophil Enzymes into the Lungs in Patients with the Adult Respiratory Distress Syndrome

1988 • 33 citations

The Role of Activation of Neutrophils and Microvascular Pressure in Acute Pulmonary Edema

1989 • 28 citations