Lymphocyte activation after non-thermal trauma

The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.

1974 • 7,802 citations

THE INJURY SEVERITY SCORE

1974 • 6,715 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

1989 • 709 citations

Sepsis syndrome

1989 • 523 citations

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

1995 • 503 citations

Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma

1996 • 390 citations

Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue.

1991 • 310 citations

Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation

1996 • 297 citations

T cell activation via Leu-23 (CD69).

1989 • 296 citations

Alteration of Monocyte Function Following Major Injury

1988 • 250 citations

Epinephrine-induced changes in the distribution of lymphocyte subsets in peripheral blood of humans.

1983 • 249 citations

Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C.

1989 • 226 citations

CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta.

1991 • 219 citations

Prostaglandin E2 (PGE2)-dependent Suppression of Interleukin α (IL-2) Production in Patients with Major Trauma

1987 • 207 citations

A systematic study of host defense processes in badly injured patients.

1986 • 182 citations

Interleukin-10 Is Associated with the Development of Sepsis in Trauma Patients

1996 • 149 citations

The Delayed Hypersensitivity Response and Host Resistance in Surgical Patients

1995 • 141 citations

Endothelial and leukocyte activation in experimental polytrauma and sepsis.

1993 • 124 citations

Dominance of T-Helper 2–Type Cytokines After Severe Injury

1996 • 123 citations

Biological variation in the development of sepsis after surgery or trauma

1993 • 119 citations

LYMPHOCYTE SUBSET RESPONSES TO TRAUMA AND SEPSIS

1993 • 118 citations

Interleukin-10

1997 • 116 citations

Kinetics of interleukin-2 and interleukin-6 synthesis following major mechanical trauma

1990 • 92 citations

Very low monocytic HLA-DR expression indicates high risk of infection - immunomonitoring for patients after neurosurgery and patients during high dose steroid therapy

1995 • 90 citations

The significance of changes in blood lymphocyte populations following surgical operations.

1984 • 73 citations

Leukocyte Responses to Injury

1993 • 71 citations

Enumeration of human lymphocyte subsets by monoclonal antibodies and flow cytometry: a comparative study using whole blood or mononuclear cells separated by density gradient centrifugation

1984 • 57 citations

Stress, cortisol concentrations, and lymphocyte subpopulations.

1985 • 56 citations

Specific changes in peripheral blood lymphocyte phenotype from burn patients. Probable origin of the thermal injury-related lymphocytopenia

1991 • 45 citations

Increase of serum interleukin 2 receptor level in thermally injured patients

1989 • 43 citations

Differential Regulation of T- and B-Lymphocyte Activation in Severely Burned Patients

1991 • 41 citations

Immunosuppression follows systemic T lymphocyte activation in the burn patient

1991 • 37 citations

The Mechanisms of Host Defense Dysfunction Following Shock and Trauma

1996 • 36 citations

Different Lymphocyte Compartments Respond Differently to Mitogenic Stimulation After Thermal Injury

1990 • 36 citations

Only a Subset of Trauma Patients with Depressed Mitogen Responses Have True T Cell Dysfunctions

1997 • 32 citations

Expression and Secretion of IL-2 Receptor in Trauma Patients

1990 • 31 citations

Postburn Impaired Cell-mediated Immunity May Not Be Due to Lazy Lymphocytes But to Overwork

1985 • 30 citations

Comparison of numerical and phenotypic leukocyte changes during constant hydrocortisone infusion in normal humans with those in thermally injured patients.

1987 • 28 citations

Immunodeficiency after major trauma and selective surgery

1988 • 25 citations

IL-2 regulation of soluble IL-2 receptor levels following thermal injury

1992 • 16 citations

Alterations in T-helper and T-suppressor lymphocyte populations after multiple injuries

1987 • 9 citations

[Changes in the cytokine concentration (Il-6, Il-8, Il-1ra) and their cellular expression of membrane molecules (CD25, CD30, HLA-DR) after surgical trauma].

1997 • 8 citations

Spontaneous lymphocyte activity: an important but neglected component of the immunologic profile of the thermally injured patient.

1985 • 7 citations

Density Gradient Purification of Mononuclear Cells Is Associated with Spurious (Artifactual) Immunosuppression

1988 • 6 citations

Kinetics of Soluble Interleukin-2 Receptor After Mechanical and Burn Trauma

1997 • 6 citations