Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

1996 • 9,565 citations

A Multiple Testing Procedure for Clinical Trials

1979 • 3,139 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Multiple Organ Dysfunction Score

1995 • 2,453 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

1990 • 991 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

Cytokine Serum Level During Severe Sepsis in Human IL-6 as a Marker of Severity

1992 • 799 citations

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1994 • 799 citations

Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group.

1998 • 618 citations

Has the mortality of septic shock changed with time?

1998 • 616 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

INTERSEPT

1996 • 492 citations

Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock

1998 • 458 citations

Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.

1994 • 387 citations

p55 Tumor Necrosis Factor Receptor Fusion Protein in the Treatment of Patients With Severe Sepsis and Septic Shock

1997 • 376 citations

Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock

1996 • 368 citations

Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

1991 • 342 citations

Monoclonal antibodies to human tumor necrosis factor α: In vitro and in vivo application

1990 • 62 citations

Factors Affecting the Measurement of Cytokines in Biological Fluids: Implications for Their Clinical Measurement

1995 • 52 citations

REPEATED ADMINISTRATION OF A F(ab′)2 FRAGMENT OF AN ANTI-TUMOR NECROSIS FACTOR α MONOCLONAL ANTIBODY IN PATIENTS WITH SEVERE SEPSIS

1994 • 37 citations