Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Insulin-like growth factor binding proteins and their role in controlling IGF actions

1997 • 510 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma

1994 • 293 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 275 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

1994 • 239 citations

Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines

1996 • 190 citations

Isolation and Characterization of Insulin-Like Growth Factor I (Somatomedin-C) from Cultures of Fetal Rat Calvariae*

1988 • 188 citations

The Insulin-Like Growth Factor-I Receptor Signaling Pathways Are Important for Tumorigenesis and Inhibition of Apoptosis

1997 • 137 citations

Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons

1997 • 120 citations

A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth.

1997 • 117 citations

Mechanisms of Bone Lesions in Multiple Myeloma

1992 • 116 citations

Interaction of Janus Kinases JAK-1 and JAK-2 with the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor¹

1998 • 111 citations

Secretion of insulinlike growth factor I and insulinlike growth factor-binding proteins by murine bone marrow stromal cells.

1991 • 108 citations

Osteoblasts and osteoclasts in adult human osteophyte tissue express the mRNAs for insulin-like growth factors I and II and the type 1 IGF receptor

1995 • 106 citations

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

1995 • 99 citations

Insulin-Like Growth Factor-1 Acts as a Chemoattractant Factor for 5T2 Multiple Myeloma Cells

1999 • 96 citations

Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6.

1996 • 86 citations

Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors

2000 • 65 citations

IFN-alpha is a survival factor for human myeloma cells and reduces dexamethasone-induced apoptosis.

1998 • 60 citations

Differential effect of growth hormone and insulin-like growth factor-I, insulin-like growth factor-II, and insulin on Ig production and growth in human plasma cells

1994 • 56 citations

Differential human multiple myeloma cell line responsiveness to interferon-alpha. Analysis of transcription factor activation and interleukin 6 receptor expression.

1997 • 49 citations

IFN-α Is a Survival Factor for Human Myeloma Cells and Reduces Dexamethasone-Induced Apoptosis

1998 • 48 citations

Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorylation of the pro-apoptotic protein BAD but not to inhibition of cytochrome c translocation in rat cerebellar neurons

2000 • 46 citations

Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction

1997 • 46 citations

Interferon-β Interrupts Interleukin-6–Dependent Signaling Events in Myeloma Cells

1997 • 40 citations

Bone marrow histology and serum beta 2 microglobulin in multiple myeloma — a new prognostic strategy

1989 • 32 citations

Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb.

1998 • 24 citations

SPECIFIC INHIBITION OF IL-6 SIGNALLING WITH MONOCLONAL ANTIBODIES AGAINST THE gp130 RECEPTOR

1997 • 19 citations