Analysis of IL-6-mediated growth control of myeloma cells using a gp130 chimeric receptor approach

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Interleukin‐6: Structure‐function relationships

1997 • 358 citations

Quantitative Imaging of Lateral ErbB1 Receptor Signal Propagation in the Plasma Membrane

2000 • 346 citations

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma

1994 • 293 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors

1999 • 241 citations

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.

1996 • 223 citations

Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells

1999 • 170 citations

JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen‐activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

2000 • 170 citations

A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis

2000 • 112 citations

IL-6 Type Cytokine Receptor Complexes: Hexamer, Tetramer or Both?

1999 • 105 citations

Box 3-independent Signaling Mechanisms Are Involved in Leukemia Inhibitory Factor Receptor α- and gp130-mediated Stimulation of Mitogen-activated Protein Kinase

1997 • 101 citations

The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction

2000 • 93 citations

Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line.

1994 • 87 citations

Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6.

1996 • 86 citations

Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.

1997 • 73 citations

Coexistence of aneuploid subclones within a myeloma cell line that exhibits clonal immunoglobulin gene rearrangement: clinical implications.

1993 • 73 citations

Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells.

1997 • 64 citations

Separate Signaling Mechanisms Are Involved in the Control of STAT Protein Activation and Gene Regulation via the Interleukin 6 Response Element by the Box 3 Motif of gp130

1995 • 60 citations

Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells.

1995 • 56 citations

Tyrosine Phosphorylation of Jak-Tyk Kinases in Malignant Plasma Cell Lines Growth Stimulated by Interleukins 6 and 11

1994 • 51 citations

Interferon-β Interrupts Interleukin-6–Dependent Signaling Events in Myeloma Cells

1997 • 40 citations

Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells.

1994 • 39 citations

Interleukin‐6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP‐1

1996 • 34 citations

Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin‐6

1997 • 30 citations

Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors

1999 • 29 citations

EGF is incomplete mitogen in porcine aortic smooth muscle cells: DNA synthesis without cell division

1992 • 23 citations

Involvement of Stat3 in interleukin‐6‐induced IgM production in a human B‐cell line

1997 • 20 citations