A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

IgG1 plasmacytosis in interleukin 6 transgenic mice.

1989 • 597 citations

Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

2002 • 467 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells

2002 • 420 citations

Myeloid cell factor–1 is a critical survival factor for multiple myeloma

2002 • 365 citations

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

1997 • 357 citations

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2.

1995 • 296 citations

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma

1994 • 293 citations

MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

2002 • 265 citations

IL-6 up-regulates Mcl-1 in human myeloma cells through JAK / STAT rather than Ras / MAP kinase pathway

1999 • 249 citations

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

1992 • 234 citations

Apaf-1/Cytochrome c-independent and Smac-dependent Induction of Apoptosis in Multiple Myeloma (MM) Cells

2001 • 202 citations

IRTA1 and IRTA2, Novel Immunoglobulin Superfamily Receptors Expressed in B Cells and Involved in Chromosome 1q21 Abnormalities in B Cell Malignancy

2001 • 186 citations

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes

2001 • 186 citations

Exon Skipping in Mcl-1 Results in a Bcl-2 Homology Domain 3 Only Gene Product That Promotes Cell Death

2000 • 184 citations

Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils

2001 • 180 citations

JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen‐activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

2000 • 170 citations

Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures

1994 • 166 citations

Mcl‐1 and Bcl‐x_L are co‐regulated by IL‐6 in human myeloma cells

1999 • 157 citations

Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts

2002 • 156 citations

Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells

1992 • 137 citations

Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1

2000 • 133 citations

BOD (Bcl-2-Related Ovarian Death Gene) Is an Ovarian BH3 Domain-Containing Proapoptotic Bcl-2 Protein Capable of Dimerization with Diverse Antiapoptotic Bcl-2 Members

1998 • 128 citations

Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines.

1989 • 107 citations

Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B‐cell lymphoma and multiple myeloma

2001 • 92 citations

In vivo interleukin 6 gene expression in the tumoral environment in multiple myeloma

1991 • 91 citations

Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6.

1996 • 86 citations

A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death

1999 • 82 citations

Increased MCL–1 Expression Is Associated with Poor Prognosis in Ovarian Carcinomas

2002 • 81 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 66 citations

Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors

2000 • 65 citations

Human and Mouse Chromosomal Mapping of the Myeloid Cell Leukemia-1 Gene: MCL1 Maps to Human Chromosome 1q21, a Region That Is Frequently Altered in Preneoplastic and Neoplastic Disease

1994 • 54 citations

Expression of Bcl-2 family of proteins in fresh myeloma cells

1998 • 53 citations

Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis.

2001 • 50 citations

The biology of multiple myeloma

2000 • 47 citations

Normal and neoplastic human plasma cells express bcl-2 antigen.

1991 • 47 citations

The effects on growth and survival of IL‐6 can be dissociated in the U‐266‐1970/U‐266‐1984 and HL407E/HL407L human multiple myeloma cell lines

1997 • 20 citations

SPECIFIC INHIBITION OF IL-6 SIGNALLING WITH MONOCLONAL ANTIBODIES AGAINST THE gp130 RECEPTOR

1997 • 19 citations

Unusual Presentation of Multiple Myeloma with “Jumping Translocation” Involving 1q21

1998 • 17 citations

Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures

1994 • 14 citations

Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells

1992 • 13 citations

[Biology of multiple myeloma].

1994 • 2 citations