Cooperation between Syk and Rac1 Leads to Synergistic JNK Activation in T Lymphocytes

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

AP-1 function and regulation

1997 • 2,833 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

T cell antigen receptor signal transduction

1997 • 390 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

1992 • 338 citations

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.

1993 • 323 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

1996 • 286 citations

Control of the ERK MAP kinase cascade by Ras and Raf.

1996 • 249 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Phospholipase C-γ1 Interacts with Conserved Phosphotyrosyl Residues in the Linker Region of Syk and Is a Substrate for Syk

1996 • 230 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Differential Intrinsic Enzymatic Activity of Syk and Zap-70 Protein-tyrosine Kinases

1996 • 179 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

1996 • 168 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.

1995 • 151 citations

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

1996 • 132 citations

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

1995 • 130 citations

Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways.

1996 • 123 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

Activation of p56^lck by p72^syk through Physical Association and N-Terminal Tyrosine Phosphorylation†

1994 • 94 citations

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

1992 • 89 citations

p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.

1995 • 80 citations

Regulation of Interleukin-2 Transcription by Inducible Stable Expression of Dominant Negative and Dominant Active Mitogen-activated Protein Kinase Kinase Kinase in Jurkat T Cells

1996 • 72 citations

Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.

1994 • 64 citations

Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation.

1994 • 59 citations

T cell antigen receptor signal transduction pathways.

1996 • 49 citations

Reconstitution of T Cell Antigen Receptor‐Induced Erk2 Kinase Activation in Lck‐Negative JCaM1 Cells by Syk

1997 • 47 citations

Syk Mutation in Jurkat E6-derived Clones Results in Lack of p72syk Expression

1995 • 35 citations