Diacylglycerol Kinase Inhibition Prevents IL-2-Induced G1 to S Transition Through a Phosphatidylinositol-3 Kinase-Independent Mechanism

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

Activation of Cyclin-Dependent Kinase 4 (cdk4) by Mouse MO15-Associated Kinase

1994 • 197 citations

Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase

1997 • 184 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase

1991 • 166 citations

Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.

1993 • 143 citations

Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.

1994 • 129 citations

IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase.

1991 • 126 citations

Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation

1996 • 118 citations

Interleukin 2- and Polyomavirus Middle T Antigen-Induced Modification of Phosphatidylinositol 3-Kinase Activity in Activated T Lymphocytes

1991 • 98 citations

Interleukin-2-Triggered Raf-1 Expression, Phosphorylation, and Associated Kinase Activity Increase through G₁ and S in CD3-Stimulated Primary Human T Cells

1991 • 82 citations

Diacylglycerol kinase

1997 • 81 citations

Analysis of Interleukin-2-dependent Signal Transduction through the Shc/Grb2 Adapter Pathway

1995 • 75 citations

The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: Implications for cytokine pleiotropy and redundancy

1994 • 54 citations

IL-4 Selectively Inhibits IL-2-Triggered Stat5 Activation, But Not Proliferation, in Human T Cells

1999 • 47 citations

Dual Role of Ceramide in the Control of Apoptosis Following IL-2 Withdrawal

1998 • 31 citations

Regulation of interleukin‐2 responses by phosphatidic acid

1992 • 27 citations

The Role of Diacylglycerol Kinase Activation and Phosphatidate Accumulation in Interleukin-2-Dependent Lymphocyte Proliferation

1993 • 21 citations

Three Distinct IL-2 Signaling Pathways Mediated by bcl-2, c-myc, and lck Cooperate in Hematopoietic Cell Proliferation.

1996 • 20 citations

Interleukin‐2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation

1998 • 10 citations