Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

de la Chapelle, A.

1997 • 3,184 citations

Handbook of Experimental Immunology.

1968 • 2,480 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

The LY‐1B Cell Lineage

1986 • 603 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

1996 • 362 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

1993 • 243 citations

Mouse Ly-49A Interrupts Early Signaling Events in Natural Killer Cell Cytotoxicity and Functionally Associates with the SHP-1 Tyrosine Phosphatase

1997 • 216 citations

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.

1996 • 214 citations

"Viable motheaten," a new allele at the motheaten locus. I. Pathology.

1984 • 205 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.

1996 • 200 citations

Regulation of Colony-Stimulating Factor 1 Receptor Signaling by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1996 • 199 citations

Motheaten, an Immunodeficient Mutant of the Mouse: I. Genetics and pathology

1975 • 198 citations

Genetically Determined Murine Models of Immunodeficiency

1987 • 178 citations

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

1996 • 167 citations

Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.

1994 • 159 citations

Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1.

1992 • 124 citations

Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis

1995 • 123 citations

Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase

1995 • 121 citations

Phosphotyrosine‐dependent association between CD22 and protein tyrosine phosphatase 1C

1995 • 120 citations

Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.

1993 • 117 citations

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.

1996 • 108 citations

Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).

1989 • 105 citations

B and T cells are not required for the viable motheaten phenotype.

1996 • 79 citations

A signaling pathway governing early thymocyte maturation

1995 • 76 citations

Pleiotropic Effects of Deleterious Alleles at the “Motheaten” Locus

1988 • 57 citations

Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice.

1997 • 52 citations

Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells.

1996 • 47 citations

Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells.

1986 • 47 citations

Involvement of the Protein Tyrosine Phosphatase SHP-1 in Ras-Mediated Activation of the Mitogen-Activated Protein Kinase Pathway

1996 • 45 citations

Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice.

1987 • 43 citations

Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice.

1988 • 41 citations

Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect.

1996 • 39 citations

Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.

1993 • 37 citations

The interaction of the xid and me genes.

1987 • 36 citations

Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.

1987 • 35 citations

Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice.

1991 • 31 citations

Tyrosine Phosphatases and the Antibody Response

1995 • 21 citations

Surface expression of hemopoietic cell phosphatase fails to complement CD45 deficiency and inhibits TCR-mediated signal transduction in a Jurkat T cell clone.

1997 • 20 citations

Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.

1987 • 18 citations

Phorbol ester responsiveness of murine Ly‐1‐lineage B cells from normal and viable motheaten mutant mice

1991 • 18 citations

Lack of requirement for SHP-1 in both Fas-mediated and perforin-mediated cell death induced by CTL.

1996 • 14 citations

Thymic Involution in Viable Motheaten (me^υ) Mice is Associated with a Loss of Intrathymic Precursor Activity

1992 • 11 citations

Function of the Common β Subunit of the GM-CSF/IL-3/IL-5 Receptors

1994 • 10 citations