Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactions

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

A protein factor essential for microtubule assembly.

1975 • 2,863 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Microtubule Assembly in the Absence of Added Nucleotides

1973 • 2,055 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

1994 • 704 citations

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

1986 • 704 citations

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

1998 • 469 citations

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.

1992 • 463 citations

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

1998 • 459 citations

High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands

1999 • 419 citations

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

1991 • 310 citations

Microtubule-Associated Protein Tau

1998 • 287 citations

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutations

1999 • 285 citations

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1999 • 207 citations

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

1992 • 167 citations

Two Separate 18-Amino Acid Domains of Tau Promote the Polymerization of Tubulin

1989 • 167 citations

Microtubular reorganization and dendritic growth response in alzheimer's disease

1989 • 159 citations

A distinct familial presenile dementia with a novel missense mutation in the tau gene

1999 • 156 citations

Separation of tubulin from microtubule-associated proteins on phosphocellulose. Accompanying alterations in concentrations of buffer components

1979 • 113 citations

τ Protein from Alzheimer's Disease Patients Is Glycated at Its Tubulin‐Binding Domain

1995 • 107 citations

Microtubule Assembly: A Review of Progress, Principles, and Perspectives

1984 • 101 citations

Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy

1995 • 94 citations

Microtubule-associated protein 2 alters the dynamic properties of microtubule assembly and disassembly

1993 • 91 citations

Protein Kinase F_A/GSK‐3 Phosphorylates on Ser²³⁵‐Pro and Ser⁴⁰⁴‐Pro that Are Abnormally Phosphorylated in Alzheimer's Disease Brain

1993 • 80 citations

Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in Diffuse Lewy body disease, Pick’s disease, and Corticobasal Degeneration

1996 • 64 citations

Chapter 3 Assembly-Disassembly Purification and Characterization of Microtubule Protein without Glycerol

1982 • 56 citations

Characterization of In Vitro Glycation Sites of Tau

1997 • 36 citations

The tau mutation (val337met) disrupts cytoskeletal networks of microtubules

1999 • 34 citations

The State of Phosphorylation of Normal Adult Brain τ, Fetal τ, and τ from Alzheimer Paired Helical Filaments at Amino Acid Residue Ser²⁶²

1996 • 16 citations

Stabilization of microtubule protein in glycerol solutions

1981 • 16 citations

Polymerization and colchicine binding

1978 • 11 citations