Pre-mRNA splicing in the new millennium

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity

2000 • 1,067 citations

Sorting out the complexity of SR protein functions

2000 • 1,064 citations

Alternative pre-mRNA splicing: the logic of combinatorial control

2000 • 892 citations

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

2000 • 689 citations

Frequent Alternative Splicing of Human Genes

1999 • 553 citations

Protein Diversity from Alternative Splicing

2000 • 548 citations

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes

2001 • 480 citations

An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN

2000 • 428 citations

Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1

2000 • 354 citations

The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

2000 • 333 citations

Splicing Defects in the Ataxia-Telangiectasia Gene, ATM: Underlying Mutations and Consequences

1999 • 313 citations

Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

2000 • 312 citations

Htra2-β 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 ( SMN2 )

2000 • 310 citations

The Apoptosis-Promoting Factor TIA-1 Is a Regulator of Alternative Pre-mRNA Splicing

2000 • 277 citations

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome

2000 • 252 citations

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing

2000 • 231 citations

Like Attracts Like: Getting RNA Processing Together in the Nucleus

2000 • 215 citations

Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase

2001 • 205 citations

Multiple Splicing Defects in an Intronic False Exon

2000 • 204 citations

Selection of Alternative 5′ Splice Sites: Role of U1 snRNP and Models for the Antagonistic Effects of SF2/ASF and hnRNP A1

2000 • 197 citations

The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site

2000 • 195 citations

Multisite RNA Binding and Release of Polypyrimidine Tract Binding Protein during the Regulation of c-src Neural-Specific Splicing

2000 • 193 citations

Functional Association of U2 snRNP with the ATP-Independent Spliceosomal Complex E

2000 • 192 citations

Pre-mRNA splicing in the absence of an SR protein RS domain

2000 • 177 citations

Functional characterization of SR and SR-related genes in Caenorhabditis elegans

2000 • 166 citations

The question remains: is the spliceosome a ribozyme?

2000 • 163 citations

Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients

2000 • 155 citations

An Intronic Splicing Silencer Causes Skipping of the IIIb Exon of Fibroblast Growth Factor Receptor 2 through Involvement of Polypyrimidine Tract Binding Protein

2000 • 153 citations

SC35 Plays a Role in T Cell Development and Alternative Splicing of CD45

2001 • 147 citations

Animal models of spinal muscular atrophy

2000 • 136 citations

RNA processing and human disease

2000 • 135 citations

Functional Recognition of the 5′ Splice Site by U4/U6.U5 tri-snRNP Defines a Novel ATP-Dependent Step in Early Spliceosome Assembly

2000 • 132 citations

Aberrant Splicing of tau Pre-mRNA Caused by Intronic Mutations Associated with the Inherited Dementia Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17

2000 • 131 citations

The SR protein B52/SRp55 is essential for Drosophila development.

1994 • 112 citations

RNA helicase dynamics in pre-mRNA splicing

2000 • 110 citations

A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing

2000 • 98 citations

SURVEY AND SUMMARY: Analysis of the splicing machinery in fission yeast: a comparison with budding yeast and mammals

2000 • 98 citations

Pre-Messenger RNA Processing Factors in the Drosophila Genome

2000 • 93 citations

An Intronic Splicing Enhancer Binds U1 snRNPs To Enhance Splicing and Select 5′ Splice Sites

2000 • 88 citations

An Upstream AG Determines Whether a Downstream AG Is Selected during Catalytic Step II of Splicing

2001 • 86 citations

Dynamic Exchanges of RNA Interactions Leading to Catalytic Core Formation in the U12-Dependent Spliceosome

2001 • 80 citations

A Yeast Intronic Splicing Enhancer and Nam8p Are Required for Mer1p-Activated Splicing

2000 • 76 citations

ATP can be dispensable for prespliceosome formation in yeast

2000 • 67 citations

Identification and Characterization of a Novel Serine-Arginine-Rich Splicing Regulatory Protein

2000 • 51 citations

Evidence for a linear search in bimolecular 3′ splice site AG selection

2000 • 50 citations

Genetic Enhancement of RNA-Processing Defects by a Dominant Mutation in B52, the Drosophila Gene for an SR Protein Splicing Factor

1995 • 42 citations

SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development

2000 • 40 citations

Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development

2000 • 40 citations

Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene

2000 • 33 citations

Pre-mRNA Splicing by the Essential Drosophila Protein B52: Tissue and Target Specificity

2000 • 31 citations

Role of adenine functional groups in the recognition of the 3′-splice-site AG during the second step of pre-mRNA splicing

2000 • 9 citations