Cytokines that regulate autoimmune responses

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Other Functions, Other Genes

1999 • 686 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.

1990 • 372 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

1994 • 331 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

1998 • 315 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

The Role of Macrophages in T Cell–mediated Autoimmune Diabetes in Nonobese Diabetic Mice

1999 • 279 citations

The role of IL-12 in the induction of organ-specific autoimmune diseases

1995 • 277 citations

Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes

1999 • 269 citations

Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

1997 • 238 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

Interleukin 12 Protects from a T Helper Type 1–mediated Autoimmune Disease, Experimental Autoimmune Uveitis, through a Mechanism Involving Interferon γ, Nitric Oxide, and Apoptosis

1999 • 210 citations

Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

1998 • 195 citations

IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation.

1999 • 192 citations

IL-12 unmasks latent autoimmune disease in resistant mice.

1996 • 182 citations

TGF-β1 Alters APC Preference, Polarizing Islet Antigen Responses toward a Th2 Phenotype

1998 • 180 citations

Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice

1996 • 180 citations

Primary demyelination in transgenic mice expressing interferon-γ

1997 • 180 citations

Microbial products induce autoimmune disease by an IL-12-dependent pathway.

1997 • 170 citations

Cellular and Molecular Mechanisms for the Initiation and Progression of β Cell Destruction Resulting from the Collaboration Between Macrophages and T Cells

1998 • 164 citations

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

1996 • 162 citations

IFN-γ Up-Regulates the A2B Adenosine Receptor Expression in Macrophages: A Mechanism of Macrophage Deactivation

1999 • 148 citations

Antibodies Against IL-12 Prevent Superantigen-Induced and Spontaneous Relapses of Experimental Autoimmune Encephalomyelitis

1998 • 145 citations

Regulation of autoimmunity by proinflammatory cytokines

1998 • 140 citations

A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus

1999 • 136 citations

Deviation of pancreas‐infiltrating cells to Th2 by interleukin‐12 antagonist administration inhibits autoimmune diabetes

1997 • 126 citations

Preferential Infiltration of Macrophages During Early Stages of Insulitis in Diabetes-Prone BB Rats

1988 • 118 citations

Interleukin‐12 regulates the proliferation of Th1, but not Th2 or Th0, clones

1994 • 118 citations

Distinct Macrophage Subpopulations in Pancreas of Prediabetic BB/E Rats: Possible Role for Macrophages in Pathogenesis of IDDM

1988 • 116 citations

Endogenous IL-12 Is Required for Induction and Expression of Experimental Autoimmune Uveitis

1998 • 110 citations

Regulation of Interleukin (IL)-12 Receptor β2 Subunit Expression by Endogenous IL-12: A Critical Step in the Differentiation of Pathogenic Autoreactive T Cells

1999 • 103 citations

Mechanism Underlying Counterregulation of Autoimmune Diabetes by IL-4

1997 • 100 citations

IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse.

1988 • 94 citations

Differential regulation of class II MHC determinants on macrophages by IFN-gamma and IL-4.

1989 • 87 citations

Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40) 2

1997 • 86 citations

Cellular and molecular changes accompanying the progression from insulitis to diabetes

1999 • 85 citations

Central Nervous System Delivery of Interleukin 4 by a Nonreplicative Herpes Simplex Type 1 Viral Vector Ameliorates Autoimmune Demyelination

1998 • 85 citations

Pancreatic IL-4 Expression Results in Islet-Reactive Th2 Cells That Inhibit Diabetogenic Lymphocytes in the Nonobese Diabetic Mouse

1999 • 84 citations

Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice

1994 • 84 citations

Induction or Protection from Experimental Autoimmune Encephalomyelitis Depends on the Cytokine Secretion Profile of TCR Peptide-Specific Regulatory CD4 T Cells

1998 • 81 citations

IL-12 in Autoimmunity

1998 • 75 citations

Interferon-γ Enhances the Expression of the Major Histocompatibility Class I Antigens on Mouse Pancreatic Beta Cells

1985 • 75 citations

Evidence for initial involvement of macrophage in development of insulitis in NOD mice

1988 • 70 citations

Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin‐12

1997 • 66 citations

Infectious Th1 and Th2 autoimmunity in diabetes‐prone mice

1998 • 65 citations

Prevention of autoimmune diabetes mellitus in NOD mice by transgenic expression of soluble tumor necrosis factor receptor p55

1997 • 58 citations

Immunophenotypical and functional heterogeneity of dendritic cells generated from murine bone marrow cultured with different cytokine combinations: implications for anti‐tumoral cell therapy

1999 • 53 citations

Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12.

1997 • 51 citations

Prevention of a Thl Disease by a Thl, Cytokine: IL‐12 and Diabetes in, NOD Mice

1996 • 50 citations

Immunological Tolerance to a Pancreatic Antigen as a Result of Local Expression of TNFα by Islet β Cells

1997 • 48 citations

Natural suppressor activity in graft-vs-host spleen and normal bone marrow is augmented by IL 2 and interferon-gamma.

1986 • 42 citations

In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules.

1992 • 42 citations

Involvement of IFN-gamma and transforming growth factor-beta in graft-vs-host reaction-associated immunosuppression.

1993 • 41 citations

Distinct macrophage subpopulations in pancreas of prediabetic BB/E rats. Possible role for macrophages in pathogenesis of IDDM

1988 • 39 citations

Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats

1988 • 35 citations

EVIDENCE THAT IFN-7 IS RESPONSIBLE FOR NATURAL SUPPRESSOR ACTIVITY IN GVHD SPLEEN AND NORMAL BONE MARROW

1988 • 32 citations

Transgenic mice expressing IFN-gamma in pancreatic beta-cells are resistant to streptozotocin-induced diabetes

1995 • 27 citations

Interferon-gamma enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells

1985 • 18 citations

The role of infiltrating macrophages in islet destruction and regrowth in a transgenic model

1995 • 7 citations

Immunomodulatory effects of interferon-γ on autoreactive nephritogenic T-cell clones

1999 • 6 citations