Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Immunisation against heterologous type II collagen induces arthritis in mice

1980 • 1,025 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Characterization of the antibody response in mice with type II collagen–induced arthritis, using monoclonal anti–type II collagen antibodies

1986 • 400 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.

1985 • 372 citations

Interleukin‐12 profoundly up‐regulates the synthesis of antigen‐specific complement‐fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

1995 • 331 citations

Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen‐induced arthritis

1996 • 317 citations

Effects of IL-12 on helper T cell-dependent immune responses in vivo.

1994 • 294 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity.

1988 • 264 citations

Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci.

1985 • 210 citations

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice.

1995 • 198 citations

Molecular cloning and characterization of murine IL-12 genes.

1996 • 93 citations

Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes

1996 • 78 citations

Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme

1995 • 67 citations

High doses of interleukin‐12 inhibit the development of joint disease in DBA/1 mice immunized with type II collagen in complete Freund's adjuvant

1996 • 56 citations

The interleukin-12 beta subunit (p40) maps to mouse Chromosome 11

1996 • 12 citations

Immunogenetics of Animal Models of Rheumatoid Arthritis

1995 • 5 citations

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