Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

1991 • 705 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

1993 • 292 citations

Prevention of diabetes in NOD mice treated with antibody to murine IFNγ

1991 • 263 citations

Monoclonal antibodies against murine gamma interferon.

1984 • 153 citations

Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen

1990 • 108 citations