Immunological Tolerance to a Pancreatic Antigen as a Result of Local Expression of TNFα by Islet β Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 • 1,167 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.

1996 • 405 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Expression Cloning of a Protective Leishmania Antigen

1995 • 351 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

Resistance to Leishmania major Induced by Tolerance to a Single Antigen

1996 • 258 citations

Lipopolysaccharide interferes with the induction of peripheral T cell death

1995 • 240 citations

Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha.

1988 • 221 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice.

1992 • 207 citations

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

1994 • 188 citations

Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.

1989 • 180 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

1996 • 162 citations

Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I.

1996 • 156 citations

Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication.

1996 • 151 citations

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

1992 • 151 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

Tumor necrosis factor α in autoimmunity: pretty girl or old witch?

1992 • 128 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts.

1995 • 119 citations

The involvement of human tumor necrosis factors-alpha and -beta in the mixed lymphocyte reaction.

1988 • 111 citations

Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes.

1990 • 91 citations

Correlation between the Vß4+CD8+ T-cell population and theH-2 d haplotype

1990 • 89 citations

Vaccine efficacy of Salmonella strains expressing glycoprotein 63 with different promoters

1997 • 88 citations

Protection against Leishmania major infection in genetically susceptible BALB/c mice by gp63 delivered orally in attenuated Salmonella typhimurium (AroA- AroD-).

1995 • 85 citations

Prevention of autoimmune diabetes mellitus in NOD mice by transgenic expression of soluble tumor necrosis factor receptor p55

1997 • 58 citations

T Helper Subset Differentiation in the Absence of Invariant Chain

1997 • 30 citations

Selective down‐regulation of Th2 immune responses following treatment with antigen‐coupled splenocytes

1997 • 14 citations