Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

Dendritic cells and the control of immunity

1998 • 14,345 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow.

1992 • 452 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Markers of mouse macrophage development detected by monoclonal antibodies

1994 • 345 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

1996 • 340 citations

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

1994 • 331 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.

1992 • 274 citations

Nitric Oxide Primes Pancreatic β Cells for Fas-mediated Destruction in Insulin-dependent Diabetes Mellitus

1997 • 242 citations

Lipopolysaccharide interferes with the induction of peripheral T cell death

1995 • 240 citations

Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

1997 • 238 citations

Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse

1997 • 203 citations

Interferon-γ impacts at multiple points during the progression of autoimmune diabetes

1997 • 201 citations

Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice

1993 • 201 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse.

1998 • 182 citations

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

1994 • 181 citations

TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide

1994 • 179 citations

A novel MHC class II epitope expressed in thymic medulla but not cortex

1989 • 175 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

1994 • 163 citations

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

1996 • 162 citations

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

1998 • 161 citations

Genetic Control of Diabetes Progression

1997 • 148 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.

1997 • 134 citations

Transfer of Diabetes in the NOD-scid Mouse by CD4 T-Cell Clones: Differential Requirement for CD8 T-Cells

1996 • 115 citations

IFN-alpha induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2.

1996 • 96 citations

RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice.

1996 • 88 citations

Expression of the Co-stimulator Molecule B7–1 in Pancreatic β-Cells Accelerates Diabetes in the NOD Mouse

1995 • 67 citations

An Immunohistochemical Study on Organized Lymphoid Cell Infiltrates in Fetal and Neonatal Pancreases: A comparison with similar infiltrates found in the pancreas of a diabetic infant

1993 • 59 citations

Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model

1998 • 52 citations

Immunological Tolerance to a Pancreatic Antigen as a Result of Local Expression of TNFα by Islet β Cells

1997 • 48 citations

Expression of murine VCAM-1 in vitro and in different models of inflammation in vivo: correlation with immigration of monocytes

1994 • 39 citations

CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.

1997 • 37 citations

Recombinant Tumor Necrosis Factor Enhances the Locomotion of Memory and Naive B Lymphocytes From Human Tonsils Through the Selective Engagement of the Type II Receptor

1997 • 29 citations

Dendritic Cells in the Autoimmune Insulitis in NOD Mouse Models of Diabetes

1997 • 23 citations

Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.

1998 • 20 citations

Recombinant Tumor Necrosis Factor Enhances the Locomotion of Memory and Naive B Lymphocytes From Human Tonsils Through the Selective Engagement of the Type II Receptor

1997 • 20 citations

Relationship between beta cell injury and antigen presentation in NOD mice.

1995 • 18 citations