Immunophenotypical and functional heterogeneity of dendritic cells generated from murine bone marrow cultured with different cytokine combinations: implications for anti‐tumoral cell therapy

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow.

1992 • 452 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Bone Marrow–generated Dendritic Cells Pulsed with Tumor Extracts or Tumor RNA Induce Antitumor Immunity against Central Nervous System Tumors

1997 • 443 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice

1983 • 367 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2

1995 • 281 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone.

1988 • 226 citations

FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in Mice

1997 • 193 citations

Protein-Specific Helper T-Lymphocyte Formation Initiated by Dendritic Cells

1985 • 181 citations

Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro.

1995 • 157 citations

Three populations of mouse lymph node dendritic cells with different origins and dynamics

1997 • 133 citations

Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells.

1995 • 125 citations

Functional comparison of spleen dendritic cells and dendritic cells cultured in vitro from bone marrow precursors

1996 • 99 citations

Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction.

1989 • 96 citations

Peptide‐pulsed dendritic cells induce tumoricidal cytotoxic T lymphocytes from healthy donors against stably HLA‐A*0201‐binding peptides from the Melan‐A/MART‐1 self antigen

1996 • 88 citations

Generation of DC from mouse spleen cell cultures in response to GM-CSF: immunophenotypic and functional analyses.

1995 • 81 citations

The influence of interleukin (IL)-4, IL-13, and Flt3 ligand on human dendritic cell differentiation from cord blood CD34+ progenitor cells.

1998 • 71 citations

Conditional ablation of dendritic cells in transgenic mice.

1994 • 55 citations

Induction of Dendritic Cell Differentiation by Granulocyte-Macrophage Colony-Stimulating Factor, Stem Cell Factor, and Tumor Necrosis Factor α In Vitro From Lineage Phenotypes-Negative c-kit+ Murine Hematopoietic Progenitor Cells

1997 • 52 citations

In vitro generation of human dendritic cells and cell therapy.

1997 • 51 citations

Immunization by Direct DNA Inoculation Induces Rejection of Tumor Cell Challenge

1995 • 51 citations

Review: Dendritic Cells and Cancer: Progress Toward a New Cellular Therapy

1997 • 26 citations

Functional expression of the CD4 protein after cross-linking to red blood cells with a bifunctional reagent

1991 • 22 citations