Antibodies Against IL-12 Prevent Superantigen-Induced and Spontaneous Relapses of Experimental Autoimmune Encephalomyelitis

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

1991 • 400 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

1991 • 385 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production.

1995 • 316 citations

The role of IL-12 in the induction of organ-specific autoimmune diseases

1995 • 277 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

1996 • 237 citations

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor‐immunoglobulin fusion proteins

1994 • 232 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

McAlpine's Multiple sclerosis

1985 • 175 citations

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

1993 • 170 citations

Microbial products induce autoimmune disease by an IL-12-dependent pathway.

1997 • 170 citations

IL-10 fails to abrogate experimental autoimmune encephalomyelitis

1996 • 169 citations

Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis.

1995 • 153 citations

Dual role of IL-12 in early and late stages of murine collagen type II arthritis.

1997 • 152 citations

Transforming growth factor‐β inhibits interleukin‐12‐induced production of interferon‐γ by natural killer cells: A role for transforming growth factor‐β in the regulation of T cell‐independent resistance to Toxoplasma gondii

1995 • 149 citations

Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein.

1983 • 130 citations

Superantigen Mediated Shock: A Cytokine Release Syndrome

1993 • 130 citations

IL-12 induces human T cells secreting IL-10 with IFN-gamma.

1996 • 121 citations

Staphylococcal enterotoxins can reactivate experimental allergic encephalomyelitis.

1993 • 119 citations

Staphylococcal enterotoxin B and tumor‐necrosis factor‐α‐induced relapses of experimental allergic encephalomyelitis: Protection by transforming growth factor‐β and interleukin‐10

1995 • 108 citations

Engagement of major histocompatibility complex class II molecules by superantigen induces inflammatory cytokine gene expression in human rheumatoid fibroblast-like synoviocytes.

1992 • 103 citations

Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease.

1996 • 98 citations

Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat.

1997 • 93 citations

Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.

1995 • 90 citations

Disparate interaction of peptide ligand with nascent versus mature class I major histocompatibility complex molecules: comparisons of peptide binding to alternative forms of Ld in cell lysates and the cell surface.

1992 • 89 citations

Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms.

1996 • 74 citations

Role of transforming growth factor‐βthe preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B

1993 • 71 citations

The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity.

1995 • 70 citations

Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.

1997 • 61 citations

The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis

1998 • 60 citations

Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma.

1996 • 59 citations

Engagement of MHC class II molecules by staphylococcal superantigens activates src‐type protein tyrosine kinases

1994 • 54 citations

Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, bacteria, and bacterial polymers

1995 • 49 citations

Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells

1995 • 48 citations

Engagement of major histocompatibility complex class II molecules leads to nitrite production in bone marrow‐derived macrophages

1993 • 41 citations

Costimulatory receptors for the superantigen staphylococcal enterotoxin B on human vascular endothelial cells and T cells

1994 • 38 citations

Generation of autonomously pathogenic neo-autoreactive TH1 cells during the development of the determinant spreading cascade in murine autoimmune encephalomyelitis

1996 • 33 citations

Distinct antigen presenting cell-derived signals induce T_H cell proliferation and expression of effector cytokines

1992 • 29 citations

Manipulation of the superantigen‐induced lymphokine response. Selective induction of interleukin‐10 or interferon‐γ synthesis in small resting CD4⁺ T cells

1993 • 27 citations

Superantigens: The Paradox of T-Cell Activation versus Inactivation

1995 • 26 citations

Superantigen-induced human CD4+ helper/killer T cell phenomenon. Selective induction of Th1 helper/killer T cells and application to tumor immunotherapy.

1995 • 26 citations

Interleukin‐10 Induction by IL‐12: A Possible Modulatory Mechanism?

1996 • 18 citations

Agonist Properties of a Microbial Superantigen Peptide

1993 • 15 citations

Deleted Work

1955 • 0 citations

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