The Role of Growth Factor Receptors in Central Nervous System Development and Neoplasia

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

1992 • 1,514 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

A common progenitor for neurons and glia persists in rat retina late in development

1987 • 1,395 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer

1994 • 981 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics

1983 • 758 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Glial Cell Diversification in the Rat Optic Nerve

1989 • 725 citations

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

1990 • 720 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma

1993 • 698 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 670 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells

1993 • 651 citations

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

1991 • 634 citations

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.

1992 • 609 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

1990 • 573 citations

The pathway to signal achievement

1993 • 563 citations

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

1991 • 541 citations

Extracellular matrix regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro.

1985 • 538 citations

Neuronal differentiation in the Drosophila ommatidium

1987 • 532 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

1990 • 521 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

Expression and function of TRK-B and BDNF in human neuroblastomas.

1994 • 423 citations

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

1991 • 415 citations

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor

1988 • 408 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

Genetic dissection of the photoreceptor system in the compound eye of Drosophila melanogaster

1976 • 395 citations

Cloning and growth of multipotential neural precursors: Requirements for proliferation and differentiation

1993 • 381 citations

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.

1992 • 380 citations

Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro

1988 • 361 citations

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.

1991 • 346 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Growth factor signaling: Where is the specificity?

1992 • 341 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Structural and functional studies on platelet-derived growth factor.

1992 • 335 citations

Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

1993 • 333 citations

The Drosophila gene torso encodes a putative receptor tyrosine kinase

1989 • 327 citations

Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture

1989 • 318 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

1991 • 294 citations

Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci

1991 • 292 citations

EGF and TGF-α stimulate retinal neuroepithelial cell proliferation in vitro

1991 • 286 citations

Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues.

1990 • 279 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGFα

1992 • 276 citations

Platelet-derived growth factor: Identification of constituent polypeptide chains

1982 • 275 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Expression of FGF receptor gene in rat development

1991 • 264 citations

Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro

1990 • 257 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.

1994 • 244 citations

Coexpression of neurotrophins and their receptors in neurons of the central nervous system.

1993 • 242 citations

Changes in neurotrophin responsiveness during the development of cerebellar granule neurons

1992 • 240 citations

BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

1991 • 238 citations

TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.

1992 • 228 citations

Fibroblast growth factor is a mitogen for oligodendrocytes in vitro

1985 • 227 citations

Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor

1989 • 219 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms.

1993 • 218 citations

Gene Amplification in Malignant Human Gliomas: Clinical and Histopathologic Aspects

1988 • 216 citations

Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

1990 • 212 citations

Cell-cell interaction in the drosophila retina: The bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development

1988 • 209 citations

Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation.

1991 • 209 citations

A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF

1990 • 205 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.

1992 • 202 citations

Nonreceptor tyrosine protein kinases.

1993 • 183 citations

Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.

1990 • 177 citations

Expression of members of the trk family in the developing postnatal rat brain

1993 • 174 citations

The origins of cellular diversity in the mammalian central nervous system

1989 • 173 citations

Amplification of the int-2 gene in primary human breast tumors.

1988 • 172 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation

1984 • 170 citations

Immunohistochemical localization of basic fibroblast growth factor in astrocytomas.

1990 • 167 citations

The role of cell-cell interaction in the development of the drosophila visual system

1990 • 163 citations

Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.

1988 • 157 citations

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.

1993 • 155 citations

An angiogenic growth factor is expressed in human glioma cells.

1987 • 152 citations

Amplification of fgfr4 gene in human breast and gynecological cancers

1993 • 146 citations

Met expression and sarcoma tumorigenicity.

1993 • 144 citations

Basic fibroblast growth factor promotes In vitro survival and cholinergic development of rat septal neurons: Comparison with the effects of nerve growth factor

1989 • 142 citations

Differentiation signals in the CNS: Type-2 astrocyte development in vitro as a model system

1990 • 139 citations

Related fibroblast growth factor receptor genes exist in the human genome.

1990 • 131 citations

Acidic and basic fibroblast growth factors are present in glioblastoma multiforme.

1991 • 129 citations

Signal transduction and the fate of the R7 photoreceptor in Drosophila

1991 • 128 citations

ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix.

1994 • 124 citations

Expression of insulin‐like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry

1992 • 124 citations

Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products.

1992 • 122 citations

Expression of angiogenic growth factor genes in primary human astrocytomas may contribute to their growth and progression.

1991 • 112 citations

Five novel avian Eph-related tyrosine kinases are differentially expressed.

1993 • 112 citations

Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines.

1992 • 110 citations

Expression of platelet-derived growth factor and its receptors in neuroendocrine tumors of the digestive system.

1992 • 109 citations

Expression of two types of receptor for insulin-like growth factors in human malignant glioma.

1988 • 108 citations

Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme.

1994 • 104 citations

The torso receptor protein-tyrosine kinase signaling pathway: An endless story

1993 • 101 citations

The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors

1991 • 96 citations

Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.

1993 • 94 citations

Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo.

1993 • 93 citations

Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line.

1990 • 92 citations

Insulin and Insulin-Like Growth Factor I in Brain Tumors: Binding and in Vitro Effects

1989 • 87 citations

The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family

1989 • 86 citations

Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.

1991 • 84 citations

Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression.

1993 • 84 citations

Cellular Localization of Brain‐derived Neurotrophic Factor and Neurotrophin‐3 mRNA Expression in the Early Chicken Embryo

1993 • 83 citations

Genetic Aberrations in Human Brain Tumors

1994 • 79 citations

Growth factor biology and oncogene activation in human gliomas and their implications for specific therapeutic concepts

1989 • 73 citations

Development of the Drosophila retina: Inductive events studied at single cell resolution

1989 • 71 citations

[45] Cloning members of protein-tyrosine kinase family using polymerase chain reaction

1991 • 70 citations

Platelet Derived Growth Factor (PDGF) autocrine components in human tumor cell lines

1990 • 69 citations

Multiple tyrosine protein kinases in rat hippocampalneurons: isolation of Ptk-3, a receptor expressed in proliferative zones of thedeveloping brain.

1994 • 69 citations

Dominant-negative mutants of a platelet-derived growth factor gene.

1990 • 63 citations

Growth Factor Biology and Oncogene Activation in Human Gliomas and Their Implications for Specific Therapeutic Concepts

1989 • 59 citations

Insulin-Like Growth Factor-I Receptors in Human Glial Tumors

1990 • 59 citations

Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium

1990 • 59 citations

Principles of Neurosurgery

1995 • 57 citations

Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain

1992 • 57 citations

Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor.

1992 • 57 citations

Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.

1993 • 55 citations

Tyrosine kinases and their interactions with signalling proteins

1992 • 51 citations

Signal transduction and the fate of the R7 photoreceptor in drosophila

1991 • 51 citations

Expression of c-sis/platelet-derived growth factor B, insulin-like growth factor I, and transforming growth factor alpha messenger RNAs and their respective receptor messenger RNAs in primary human gastric carcinomas: in vivo studies with in situ hybridization and immunocytochemistry.

1992 • 50 citations

Protein Tyrosine Kinase Growth Factor Receptors and their Ligands in Development, Differentiation, and Cancer

1992 • 49 citations

Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro

1990 • 45 citations

Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors.

1993 • 43 citations

Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system

1993 • 40 citations

Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate

1988 • 39 citations

Nerve Growth Factor Receptor Expression in Medulloblastomas and the Potential Role of Nerve Growth Factor as a Differentiating Agent in Medulloblastoma Cell Lines

1993 • 29 citations

Complementary DNA cloning and characterization of truncated form of c-kit in human colon carcinoma cells.

1994 • 28 citations

Human central nervous system primitive neuroectodermal tumor expressing nerve growth factor receptors: CHP707M

1990 • 27 citations

Molecular cloning of a family of protein kinase genes expressed in the avian embryo.

1992 • 27 citations

Expression of c-sis and Platelet-Derived Growth Factor in in Vitro-Transformed Glioma Cells from Rat Brain Tissue Transplacentally Treated with Ethylnitrosourea

1986 • 23 citations

Platelet-derived growth factor (PDGF) receptor activation in cell transformation and human malignancy

1992 • 21 citations

Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea.

1986 • 14 citations