Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Nonparametric Estimation from Incomplete Observations

1958 • 7,673 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

A proposed staging for children with neuroblastoma.Children's cancer study group A

1971 • 967 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.

1991 • 595 citations

The neurocristopathiesA unifying concept of disease arising in neural crest maldevelopment

1974 • 591 citations

Cellular DNA Content as a Predictor of Response to Chemotherapy in Infants with Unresectable Neuroblastoma

1984 • 498 citations

Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines

1985 • 478 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Keeping track of neurotrophin receptors

1991 • 297 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development

1992 • 240 citations

Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cells.

1986 • 220 citations

Inverse relationship between trk expression and N-myc amplification in human neuroblastomas.

1992 • 219 citations

A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF

1990 • 205 citations

Different karyotypic patterns in early and advanced stage neuroblastomas.

1987 • 188 citations

Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines

1982 • 168 citations

Differentiation of human neuroblastoma recapitulates neural crest development. Study of morphology, neurotransmitter enzymes, and extracellular matrix proteins.

1987 • 161 citations

A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

1986 • 159 citations

Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+.

1991 • 159 citations

High-dose chemoradiotherapy supported by marrow infusions for advanced neuroblastoma: a Pediatric Oncology Group study.

1991 • 124 citations

Radiotherapy improves the outlook for patients older than 1 year with Pediatric Oncology Group stage C neuroblastoma.

1991 • 123 citations

Structure and developmental expression of the chicken NGF receptor

1990 • 120 citations

Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts.

1990 • 119 citations

Flow cytometric DNA analysis of Neuroblastoma and Ganglioneuroma. A 10-year retrospective study

1988 • 110 citations

A quantitative study of the developmental expression of nerve growth factor (NGF) receptor in rats

1987 • 102 citations

Sequential cyclophosphamide and doxorubicin for induction of complete remission in children with disseminated neuroblastoma

1981 • 100 citations

myc gene amplification and expression in primary human neuroblastoma.

1990 • 92 citations

Effect of retinoic acid on nerve growth factor receptors

1987 • 90 citations

Prognostic subgroups for undifferentiated neuroblastoma: Immunohistochemical study with anti-S-100 protein antibody

1985 • 89 citations

Biological classification of cell lines derived from human extra-cranial neural tumors.

1988 • 86 citations

Long-Term Tissue Culture of Neuroblastomas. II. Morphologic Evidence for Differentiation and Maturation<xref ref-type="fn" rid="FN2">2</xref>

1964 • 85 citations

Fast and slow nerve growth factor binding sites in human neuroblastoma and rat pheochromocytoma cell lines: relationship of sites to each other and to neurite formation

1985 • 84 citations

Multiple defects of the nerve growth factor receptor in human neuroblastomas.

1990 • 78 citations

Nerve Growth Factor (NGF) Induces Neuronal Differentiation in Neuroblastoma Cells Transfected with the NGF Receptor cDNA

1990 • 72 citations

Nerve growth factor receptors on chick embryo sympathetic ganglion cells: binding characteristics and development

1986 • 59 citations

Amplification and expression of the N-myc gene in neuroblastoma

1987 • 58 citations

N-myc oncogene amplification and prognostic factorsof neuroblastoma in children

1987 • 53 citations

Nerve growth factor (NGF) induces neuronal differentiation in neuroblastoma cells transfected with the NGF receptor cDNA.

1990 • 48 citations

Different genomic and metabolic patterns between mass screening-positive and mass screening-negative later-presenting neuroblastomas

1991 • 47 citations

Death of sensory ganglion neurons after acute withdrawal of nerve growth factor in dissociated cell cultures

1989 • 46 citations

Postoperative treatment of nonmetastatic visible residual neuroblastoma: a Pediatric Oncology Group study.

1991 • 43 citations

Nerve growth factor receptor expression in peripheral and central neuroectodermal tumors, other pediatric brain tumors, and during development of the adrenal gland.

1991 • 39 citations

Differentiation of neuroblastoma cells induced by nerve growth factor in vitro

1973 • 38 citations

N-myc oncogene and stage iv-s neuroblastoma preliminary observations on ten cases

1990 • 37 citations

Nerve Growth Factor Receptors in Human Neuroblastoma Cells

1987 • 37 citations

Japanese experience of screening

1989 • 24 citations

Improved survival rates in children over 1 year of age with stage III or IV neuroblastoma following an intensive chemotherapeutic regimen

1989 • 23 citations

Molecular Analysis of the Nerve Growth Factor Receptor

1988 • 23 citations

Nerve Growth Factor and Nerve Growth-Stimulating Activity in Sera From Normal and Neuroblastoma Patients<xref ref-type="fn" rid="FN2">2</xref>

1969 • 20 citations

Characterization of Two Neuroblastoma Cell Lines Expressing Recombinant Nerve Growth Factor Receptors

1991 • 19 citations

Nerve growth factor may function as a survival factor for human neuroblastoma cells in culture

1984 • 7 citations