The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Angiogenic Factors

1987 • 3,702 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Human Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial Cultivation

1983 • 801 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival.

1984 • 634 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.

1988 • 489 citations

Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.

1987 • 480 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

1987 • 422 citations

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1987 • 416 citations

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor

1988 • 408 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds

1988 • 382 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Effects of basic fibroblast growth factor on bone formation in vitro.

1988 • 375 citations

Fibroblast growth factor

1986 • 367 citations

The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer

1988 • 367 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.

1985 • 352 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Fibroblast growth factor: Structural and biological properties

1987 • 334 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

Receptor- and heparin-binding domains of basic fibroblast growth factor.

1988 • 318 citations

Interaction of endothelial cell growth factor with heparin: characterization by receptor and antibody recognition.

1985 • 301 citations

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

1987 • 285 citations

Purification of heparin-binding growth factors

1986 • 279 citations

Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells.

1988 • 276 citations

The brain fibroblast growth factor (FGF) is localized in neurons

1986 • 276 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Growth of purified astrocytes in a chemically defined medium.

1981 • 268 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

Characterization of a factor that promotes neurite outgrowth: evidence linking activity to a heparan sulfate proteoglycan.

1982 • 265 citations

Regulation of Bovine Bone Cell Proliferation by Fibroblast Growth Factor and Transforming Growth Factorβ

1988 • 264 citations

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 • 261 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Both normal and tumor cells produce basic fibroblast growth factor

1986 • 250 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 • 241 citations

bFGF as an autocrine growth factor for human melanomas.

1988 • 237 citations

Purification of two astroglial growth factors from bovine brain

1985 • 235 citations

Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowth.

1987 • 216 citations

Multiple influences of a heparin-binding growth factor on neuronal development.

1987 • 212 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Complementary DNA cloning and sequencing of rat ovarian basic fibroblast growth factor and tissue distribution study of its mRNA

1988 • 210 citations

Pituitary follicular cells produce basic fibroblast growth factor.

1987 • 200 citations

Cell surface fibroblast growth factor and epidermal growth factor receptors are permanently lost during skeletal muscle terminal differentiation in culture.

1988 • 197 citations

Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation.

1986 • 196 citations

Hormones and growth factors induce the synthesis of glial fibrillary acidic protein in rat brain astrocytes

1985 • 195 citations

Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

1987 • 194 citations

Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells

1987 • 187 citations

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

1988 • 181 citations

Heparin potentiates the action of acidic fibroblast growth factor by prolonging its biological half‐life

1989 • 181 citations

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

1986 • 178 citations

Stimulation of Growth of Keratinocytes by Basic Fibroblast Growth Factor

1988 • 172 citations

Specific binding of basic fibroblast growth factor to basement membrane‐like structures and to purified heparan sulfate proteoglycan of the EHS tumor

1988 • 172 citations

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

1988 • 171 citations

Clonal analysis of vertebrate myogenesis

1974 • 169 citations

Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cells

1987 • 163 citations

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 • 157 citations

Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells

1988 • 156 citations

Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activity.

1986 • 151 citations

Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA.

1988 • 150 citations

Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons

1988 • 149 citations

Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro

1988 • 149 citations

Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.

1988 • 149 citations

Induction of protein kinase C activation and Ca²⁺ mobilization by fibroblast growth factor in Swiss 3T3 cells

1985 • 148 citations

Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth.

1988 • 134 citations

Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.

1987 • 134 citations

Specific fixation of bovine brain and retinal acidic and basic fibroblast growth factors to mouse embryonic eye basement membranes

1987 • 133 citations

Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.

1986 • 131 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

High and low affinity binding of heparin-binding growth factor to a 130-kDa receptor correlates with stimulation and inhibition of growth of a differentiated human hepatoma cell.

1988 • 126 citations

Isolation of a rearranged human transforming gene following transfection of Kaposi sarcoma DNA.

1987 • 125 citations

Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.

1987 • 117 citations

K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells.

1988 • 115 citations

Characterization of the Neuronal Receptor for Basic Fibroblast Growth Factor and Comparison to Receptors on Mesenchymal Cells

1989 • 113 citations

Human brain-derived acidic and basic fibroblast growth factors: Amino terminal sequences and specific mitogenic activities

1986 • 112 citations

Glycosylation of the basic fibroblast growth factor receptor. The contribution of carbohydrate to receptor function.

1988 • 112 citations

The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment.

1986 • 111 citations

Acidic fibroblast growth factor atimulates adrenal chromaffin cells to proliferate and to extend neurites, but is not a long term survival factor

1988 • 109 citations

Clonal analysis of vertebrate myogenesis

1988 • 108 citations

Growth Stimulation of Rat Calvaria Osteoblastic Cells by Acidic Fibroblast Growth Factor

1987 • 106 citations

Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.

1986 • 105 citations

Basic fibroblast growth factor as a regulator of ovarian granulosa cell differentiation: a novel non-mitogenic role

1988 • 97 citations

Fibroblast growth factor treatment of Swiss 3T3 cells activates a subunit S6 kinase that phosphorylates a synthetic peptide substrate.

1986 • 96 citations

Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury

1988 • 94 citations

Basic fibroblast growth factor and insulin‐like growth factor I are strong mitogens for cultured mouse keratinocytes

1988 • 92 citations

The neurite-promoting effect of fibroblast growth factor on PC12 cells

1983 • 88 citations

Serum and fibroblast growth factor stimulate quiescent astrocytes to re-enter the cell cycle

1988 • 86 citations

Nerve growth factor regulates gene expression by several distinct mechanisms.

1989 • 86 citations

Fibroblast growth factor as an intraovarian hormone: differential regulation of steroidogenesis by an angiogenic factor

1986 • 86 citations

The genes for basic and acidic fibroblast growth factors are on different human chromosomes

1986 • 78 citations

Ultrastructural localization of fibroblast growth factor in neurons of rat brain

1987 • 77 citations

Thrombin inactivates acidic fibroblast growth factor but not basic fibroblast growth factor

1988 • 77 citations

Sulfated glycosaminoglycans modify growth factor‐induced neurite outgrowth in PC12 cells

1988 • 76 citations

A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation.

1988 • 73 citations

Identification of the fibroblast growth factor receptor in human vascular endothelial cells

1988 • 72 citations

Interactions between basic fibroblast growth factor (FGF) and glycosoaminoglycans in promoting neurite outgrowth

1988 • 71 citations

Brain-derived fibroblast growth factor: identity with a fragment of the basic protein of myelin.

1978 • 66 citations

Acidic fibroblast growth factor stimulates opsin levels in retinal photoreceptor cells in vitro

1988 • 63 citations

Purification of basic FGF receptors from rat brain

1988 • 63 citations

Comparison of the morphological effects of acidic and basic fibroblast growth factors on rat astroblasts in culture

1988 • 63 citations

Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells

1988 • 58 citations

Fibroblast Growth Factor Messenger Ribonucleic Acid Expression in a Human Astrocytoma Cell Line: Regulation by Serum and Cell Density

1988 • 54 citations

Transforming potential of fibroblast growth factor genes

1988 • 50 citations

Heparin inhibits skeletal muscle growth in vitro

1988 • 42 citations

Stimulation of aromatase activity in immature porcine Leydig cells by fibroblast growth factor (FGF)

1988 • 41 citations

Regulation of Multiple Basic Fibroblast Growth Factor Messenger Ribonucleic Acid Transcripts by Protein Kinase C Activators

1988 • 41 citations

Internalization and degradation of heparin binding growth factor-I by endothelial cells

1988 • 38 citations

Characterization of a bovine acidic FGF cDNA clone and its expression in brain and retina

1988 • 37 citations

Presence of basic fibroblast growth factor receptors in bovine brain membranes.

1988 • 37 citations

Fibroblast Growth Factors from Bovine Pituitary and Human Placenta and Their Functions in the Maturation of Porcine Granulosa Cellsin Vitro*

1988 • 36 citations

Antibodies against basic fibroblast growth factor inhibit the autocrine growth of pulmonary artery endothelial cells

1988 • 32 citations

Regulation of neuroblast proliferation by hormones and growth factors in chemically defined medium

1988 • 32 citations

The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2.

1988 • 32 citations

Structure activity relationship in heparin: Stimulation of non-vascular cells by a synthetic heparin pentasaccharide in cooperation with human acidic fibroblast growth factors

1986 • 27 citations

Estrogens, Cyclic Adenosine 3′,5′-Monophosphate, and Phorbol Esters Modulate the Prolactin Response of GH₃Cells to Basic Fibroblast Growth Factor*

1988 • 26 citations

Requirements for Brain Cell Attachment, Survival and Growth in Serum-Free Medium: Effects of Extracellular Matrix, Epidermal Growth Factor and Fibroblast Growth Factor

1985 • 24 citations

Induction of oligodendrocyte-like properties in a primitive hypothalamic cell line by cholesterol, an eye derived growth factor and brain extract.

1983 • 15 citations

Acidic heparin binding growth factor transiently activates adenylate cyclase activity in human adult arterial smooth muscle cells

1987 • 15 citations

Comparison of the effects of class 1 and class 2 heparin-binding growth factors on protein synthesis and actin mRNA expression in BALB/c-3T3 cells

1988 • 9 citations

Effect of heparin-binding growth factors on monovalent cation transport in Balb/C 3T3 cells

1987 • 9 citations

Deleted Work

1955 • 0 citations