A Major Role for TPPII in Trimming Proteasomal Degradation Products for MHC Class I Antigen Presentation

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

2002 • 4,069 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Making Sense of Marx

1985 • 776 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

Antigen processing by the proteasome

2001 • 620 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

2002 • 518 citations

Quantitating Protein Synthesis, Degradation, and Endogenous Antigen Processing

2003 • 508 citations

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues

2002 • 486 citations

Making sense of mass destruction: quantitating MHC class I antigen presentation

2003 • 426 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

2000 • 384 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products

2001 • 367 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

2001 • 322 citations

Peptide Diffusion, Protection, and Degradation in Nuclear and Cytoplasmic Compartments before Antigen Presentation by MHC Class I

2003 • 298 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

Two new proteases in the MHC class I processing pathway

2000 • 253 citations

An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope

2003 • 231 citations

Peptide size selection by the major histocompatibility complex-encoded peptide transporter.

1994 • 212 citations

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

1996 • 168 citations

The Cytosolic Endopeptidase, Thimet Oligopeptidase, Destroys Antigenic Peptides and Limits the Extent of MHC Class I Antigen Presentation

2003 • 156 citations

Export of Antigenic Peptides from the Endoplasmic Reticulum Intersects with Retrograde Protein Translocation through the Sec61p Channel

2000 • 151 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

Translocation of long peptides by transporters associated with antigen processing (TAP)

1996 • 149 citations

Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase

2001 • 147 citations

Tripeptidyl peptidases: enzymes that count

1999 • 145 citations

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

1999 • 144 citations

A simple method to eliminate the antigenicity of surface class I MHC molecules from the membrane of viable cells by acid treatment at pH 3

1987 • 133 citations

Human Bleomycin Hydrolase: Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization

1996 • 107 citations

Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein.

1997 • 93 citations

Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

2001 • 85 citations

Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase

1990 • 57 citations

Quantifying Recruitment of Cytosolic Peptides for HLA Class I Presentation: Impact of TAP Transport

2003 • 56 citations

Prolyl aminopeptidase from rat brain and kidney

1990 • 53 citations

Characterization and Cloning of Tripeptidyl Peptidase II from the Fruit Fly, Drosophila melanogaster

1998 • 41 citations

Inhibitors of Tripeptidyl Peptidase II. 2. Generation of the First Novel Lead Inhibitor of Cholecystokinin-8-Inactivating Peptidase: A Strategy for the Design of Peptidase Inhibitors

2000 • 17 citations

Design, Synthesis, and Tripeptidyl Peptidase II Inhibitory Activity of a Novel Series of (S)-2,3-Dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles

2002 • 16 citations