Inhibitors of Tripeptidyl Peptidase II. 2. Generation of the First Novel Lead Inhibitor of Cholecystokinin-8-Inactivating Peptidase: A Strategy for the Design of Peptidase Inhibitors

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Purification of Laboratory Chemicals

2003 • 8,826 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Cholecystokinin decreases food intake in rats.

1973 • 1,454 citations

The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis

1964 • 1,214 citations

Biological actions of cholecystokinin

1994 • 718 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

Immunochemical evidence of cholecystokinin-like peptides in brain

1976 • 676 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

C-terminal octapeptide of cholecystokinin decreases food intake in man

1981 • 596 citations

Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats

1985 • 369 citations

Cholecystokinin Octapeptide: Continuous Picomole Injections Into the Cerebral Ventricles of Sheep Suppress Feeding

1979 • 334 citations

Cholecystokinin suppresses food intake by inhibiting gastric emptying

1982 • 330 citations

The ascent of cholecystokinin (CCK) — From gut to brain

1982 • 241 citations

C-Terminal octapeptide of cholecystokinin decreases food intake in obese men☆☆☆

1982 • 207 citations

Herpes simplex virus DNA sequences in the CNS of latently infected mice

1980 • 180 citations

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

1996 • 168 citations

Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety

1988 • 158 citations

Satiating Effect of Cholecystokinina

1994 • 131 citations

Selective Protection of Methionine Enkephalin Released from Brain Slices by Enkephalinase Inhibition

1981 • 123 citations

Characterization and visualization of cholecystokinin receptors in rat brain using [3H]pentagastrin

1983 • 118 citations

Role of Cholecystokinin in the Regulation of Gastrointestinal Motility

1994 • 116 citations

Evidence that decreased feeding induced by systemic injection of cholecystokinin is mediated by CCK-A receptors

1989 • 116 citations

Purification, substrate specificity, and classification of tripeptidyl peptidase II.

1986 • 103 citations

Visual contrast sensitivity of a 6-month-old infant Measured by the evoked potential

1976 • 98 citations

THE USE OF HYDROGEN BROMIDE IN ACETIC ACID FOR THE REMOVAL OF CARBOBENZOXY GROUPS AND BENZYL ESTERS OF PEPTIDE DERIVATIVES¹

1954 • 94 citations

Optimization of 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists

1997 • 86 citations

Operant feeding and drinking in pigs following intracerebroventricular injection of synthetic cholecystokinin octapeptide

1981 • 84 citations

Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.

1992 • 74 citations

The ACTH ‘family tree’ of the rhesus monkey changes with development

1978 • 72 citations

Calcium Spike Electrogenesis and Other Electrical Activity in Continuously Cultured Small Cell Carcinoma of the Lung

1981 • 63 citations

Assessment of the role of “enkephalinase” in cholecystokinin inactivation

1985 • 56 citations

Effect of Cholecystokinin on Gastric Motility in Humansa

1994 • 49 citations

Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin

1991 • 45 citations

A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey

1992 • 39 citations

A serine peptidase responsible for the inactivation of endogenous cholecystokinin in brain.

1988 • 37 citations

Potent and sustained satiety actions of a cholecystokinin octapeptide analogue

1992 • 33 citations

Synthesis and Biological Evaluation of Potent, Selective, Hexapeptide CCK-A Agonist Anorectic Agents

1997 • 33 citations

THE EFFECT OF ALKALI AND ACID UPON THE ROTATORY POWER OF CERTAIN DIPEPTIDES¹

1950 • 32 citations

3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A Agonists That Demonstrate Oral Activity as Satiety Agents

1996 • 29 citations

Characterization of cDNA for murine tripeptidyl-peptidase II reveals alternative splicing

1994 • 27 citations

Protection by serine peptidase inhibitors of endogenous cholecystokinin released from brain slices

1989 • 27 citations

CCK_26–33 Degrading Activity in Brain and Nonneural Tissue: A Metalloendopeptidase

1985 • 26 citations

The design of a dipeptide library for screening at peptide receptor sites

1993 • 25 citations

Human pancreatic and biliary responses to physiological concentrations of cholecystokinin octapeptide

1985 • 22 citations

Purification and characterization of tripeptidylpeptidase-II from post-mortem human brain

1993 • 22 citations

Stimulation of Abducens Nucleus Supports Classical Conditioning of the Nictitating Membrane Response

1979 • 22 citations

Investigation on the metabolism of CCK8 analogues by rat brain slices

1986 • 21 citations

The Betaines of 3-Hydroxyproline. Assignment of Configuration and Inhibition of Acetylcholinesterase

1964 • 21 citations

Role of a serine endopeptidase in the hydrolysis of exogenous cholecystokinin by brain slices

1989 • 17 citations

Modification of Receptor Selectivity and Functional Activity in Cholecystokinin Peptoid Ligands

1995 • 16 citations

Further Applications of Pentachlorophenyl Active Esters in Lengthening Peptide Chains from C- and N-Terminal Amino Acids Using Dicyclohexylamine C-Protection

1968 • 10 citations

Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus

1994 • 9 citations

Novel Asp32-Replacement Tetrapeptide Analogs as Potent and Selective CCK-A Agonists

1994 • 8 citations

[On the functions of thiol groups of aspartate-glutamate transaminase].

1965 • 4 citations

Syntheses of 3‐Cyanopropan‐ and 4‐Aminobutanamides

1982 • 2 citations

[Synthesis of beta-alanine peptides].

1968 • 1 citations