Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Four deaths and a funeral: from caspases to alternative mechanisms

2001 • 1,605 citations

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

2002 • 1,352 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1999 • 887 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

2000 • 765 citations

Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis

1998 • 725 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1

2002 • 674 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Glutamate-induced neuron death requires mitochondrial calcium uptake

1998 • 623 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

The harlequin mouse mutation downregulates apoptosis-inducing factor

2002 • 595 citations

Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart

1996 • 543 citations

Molecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death

2001 • 532 citations

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

1981 • 530 citations

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

2000 • 527 citations

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

2002 • 485 citations

The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

1991 • 471 citations

Apoptosis‐inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

2000 • 459 citations

Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis

1999 • 431 citations

Mitochondrial endonuclease G is important for apoptosis in C. elegans

2001 • 416 citations

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

1996 • 413 citations

The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection

1992 • 400 citations

ADP-ribosylation in mammalian cell ghosts. Dependence of poly(ADP-ribose) synthesis on strand breakage in DNA.

1980 • 378 citations

Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans

2002 • 375 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

Intracellular ATP, a switch in the decision between apoptosis and necrosis

1998 • 353 citations

DNA binding is required for the apoptogenic action of apoptosis inducing factor

2002 • 342 citations

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation

2001 • 340 citations

Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism

2001 • 316 citations

The world according to PARP

2001 • 315 citations

Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases

2001 • 314 citations

Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis

2002 • 314 citations

Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

2002 • 312 citations

The Shape of Cell Death

1997 • 302 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

1999 • 292 citations

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1999 • 286 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

2000 • 269 citations

Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase

1998 • 268 citations

Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite

2002 • 249 citations

Apoptosis without caspases: an inefficient molecular guillotine?

1999 • 247 citations

Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor

2001 • 244 citations

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

2000 • 236 citations

Failure of Poly(ADP-Ribose) Polymerase Cleavage by Caspases Leads to Induction of Necrosis and Enhanced Apoptosis

1999 • 228 citations

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

2000 • 216 citations

TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression

2001 • 215 citations

Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex

2000 • 213 citations

AMID, an Apoptosis-inducing Factor-homologous Mitochondrion-associated Protein, Induces Caspase-independent Apoptosis

2002 • 211 citations

Structure and function of poly(ADP-ribose) polymerase

1994 • 206 citations

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

2001 • 203 citations

Caspase-Dependent and -Independent Death of Camptothecin-Treated Embryonic Cortical Neurons

1999 • 200 citations

Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

1998 • 199 citations

Poly(ADP-ribose) Polymerase-1 in the Nervous System

2000 • 196 citations

Excitotoxicity: Perspectives Based onN-Methyl-d-Aspartate Receptor Subtypes

2002 • 195 citations

The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.

1967 • 194 citations

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

1989 • 192 citations

Procaspase-3 and Poly(ADP)ribose Polymerase (PARP) Are Calpain Substrates

1999 • 180 citations

The crystal structure of the mouse apoptosis-inducing factor AIF

2002 • 178 citations

Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1

2001 • 173 citations

In Utero Ethanol Exposure Causes Mitochondrial Dysfunction, Which Can Result in Apoptotic Cell Death in Fetal Brain: A Potential Role for 4‐Hydroxynonenal

2001 • 158 citations

Neuroprotective Effects of Inhibiting Poly(ADP-Ribose) Synthetase on Focal Cerebral Ischemia in Rats

1997 • 158 citations

Reduction of Cognitive and Motor Deficits after Traumatic Brain Injury in Mice Deficient in Poly(ADP-Ribose) Polymerase

1999 • 158 citations

Myocardial Postischemic Injury Is Reduced by PolyADPribose Polymerase-1 Gene Disruption

2000 • 153 citations

Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.

1995 • 148 citations

Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia

2001 • 143 citations

Critical role of photoreceptor apoptosis in functional damage after retinal detachment

2002 • 142 citations

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

1997 • 141 citations

Apoptosis‐Inducing Factor Mediates Microglial and Neuronal Apoptosis Caused by Pneumococcus

2001 • 131 citations

Poly(ADP-Ribose) Polymerase Impairs Early and Long-Term Experimental Stroke Recovery

2002 • 129 citations

Pharmacologic Inhibition of Poly(ADP-Ribose) Polymerase Is Neuroprotective Following Traumatic Brain Injury in Rats

2001 • 128 citations

Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease

2003 • 125 citations

Inhibition of Poly(ADP-Ribose) Polymerase

1998 • 125 citations

Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1

2000 • 125 citations

Poly(ADP‐ribose) polymerase: Early involvement in glutamate‐induced neurotoxicity in cultured cerebellar granule cells

1994 • 122 citations

A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis

2001 • 113 citations

Activation of Poly(ADP‐Ribose) Polymerase in the Rat Hippocampus May Contribute to Cellular Recovery Following Sublethal Transient Global Ischemia

2000 • 106 citations

A novel p53‐inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis‐inducing factor (AIF)

2002 • 105 citations

Mitochondrial Release of Apoptosis-Inducing Factor and Cytochrome c During Smooth Muscle Cell Apoptosis

2001 • 98 citations

Poly(ADP‐Ribose) Synthase Inhibition Reduces Ischemic Injury and Inflammation in Neonatal Rat Brain

2000 • 94 citations

Calpains Mediate p53 Activation and Neuronal Death Evoked by DNA Damage

2003 • 92 citations

Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult

2000 • 92 citations

Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide

1998 • 87 citations

Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57Bl/6 mice

1996 • 84 citations

Inhibitors of the activity of poly (ADP‐ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts

1998 • 70 citations

Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway

2002 • 70 citations

Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment

2001 • 68 citations

Translocation of apoptosis‐inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress

2002 • 63 citations

Apoptosis and necrosis occurring in excitotoxic cell death in isolated chick embryo retina

2001 • 52 citations

Survival and Proliferation of Cells Expressing Caspase-uncleavable Poly(ADP-ribose) Polymerase in Response to Death-inducing DNA Damage by an Alkylating Agent

1999 • 45 citations

Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse

1996 • 45 citations

Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice

1996 • 41 citations

Molecular mechanisms of sulfasalazine‐induced T‐cell apoptosis

2002 • 40 citations

Role of caspases and apoptosis-inducing factor (AIF) in cladribine-induced apoptosis of B cell chronic lymphocytic leukemia

2002 • 37 citations

Hydrogen peroxide-induced motoneuron apoptosis is prevented by poly ADP ribosyl synthetase inhibitors

1998 • 34 citations