Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Parkinson's Disease

1998 • 1,953 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Parkinson's Disease

1998 • 1,150 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

1996 • 626 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

1999 • 545 citations

Nitric oxide neurotoxicity

1996 • 496 citations

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1997 • 460 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

Poly(ADP-ribose) levels in carcinogen-treated cells

1979 • 346 citations

Excitotoxicity and nitric oxide in parkinson's disease pathogenesis

1998 • 285 citations

NAD⁺ as a metabolic link between DNA damage and cell death

2004 • 261 citations

Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

1984 • 241 citations

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

2000 • 216 citations

Effects of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine and 1‐Methyl‐4‐Phenylpyridinium Ion on Activities of the Enzymes in the Electron Transport System in Mouse Brain

1987 • 214 citations

Nitric Oxide Toxicity in Islet Cells Involves Poly(ADP-Ribose) Polymerase Activation and Concomitant NAD+ Depletion

1994 • 188 citations

The etiology of Parkinson's disease with emphasis on the MPTP story

1996 • 181 citations

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium

1993 • 171 citations

Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse

1989 • 141 citations

Clinical observations on the rate of progression of idiopathic parkinsonism

1994 • 137 citations

Pathogenesis of Parkinson's disease.

2001 • 105 citations

Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism

1998 • 104 citations

New Animal Models for Parkinson's Disease

2000 • 98 citations

Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide

1998 • 87 citations

Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57Bl/6 mice

1996 • 84 citations

Nigral dopaminergic cell loss in vitamin E deficient rats

1994 • 46 citations

6-hydroxydopamine-induced nuclear factor-kappaB activation in PC12 cells22Abbreviations: 6-OHDA, 6-hydroxydopamine; EMSA, electrophoretic mobility shift assay; GSH, glutathione; IAP, inhibitory apoptosis protein; MAP, mitogen-activated protein; NAC, N-acetyl-cystein; NF-κB, nuclear factor-κB; and PD, Parkinson’s disease.

2001 • 44 citations

Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice

1996 • 41 citations

Selective isolation of domains of chromatin proximal to both carcinogen-induced DNA damage and poly-adenosine diphosphate-ribosylation.

1985 • 27 citations

Neurotoxicity and the mechanisms of cell death in Parkinson's disease.

1996 • 22 citations

Poly(ADP‐Ribose) Polymerase (PARP) Revisited

1997 • 17 citations

Oxidation of tetrahydrostilbazole by monoamine oxidase A demonstrates the effect of alternate pathways in the kinetic mechanism

1993 • 10 citations