Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.

1990 • 1,142 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics

1999 • 928 citations

Brain ischemia and reperfusion: molecular mechanisms of neuronal injury

2000 • 791 citations

Inflammation and glial responses in ischemic brain lesions

1998 • 788 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Nitric Oxide Synthase in Models of Focal Ischemia

1997 • 659 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Synaptogenesis and FOS Expression in the Motor Cortex of the Adult Rat after Motor Skill Learning

1996 • 541 citations

Neocortical Neural Sprouting, Synaptogenesis, and Behavioral Recovery After Neocortical Infarction in Rats

1995 • 520 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1999 • 518 citations

Correlation Between Motor Impairment and Infarct Volume After Permanent and Transient Middle Cerebral Artery Occlusion in the Rat

1997 • 400 citations

Motor Skills Training Enhances Lesion-Induced Structural Plasticity in the Motor Cortex of Adult Rats

1999 • 381 citations

Enhanced Neocortical Neural Sprouting, Synaptogenesis, and Behavioral Recovery With <scp>d</scp> -Amphetamine Therapy After Neocortical Infarction in Rats

1998 • 347 citations

Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat

1995 • 346 citations

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia–reperfusion injury in the heart and skeletal muscle

1997 • 310 citations

Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects

1997 • 284 citations

Reperfusion Injury after Focal Cerebral Ischemia: The Role Inflammation and the The rapeutic Horizon

1998 • 266 citations

Free radicals in central nervous system ischemia.

1990 • 251 citations

Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats

1992 • 233 citations

Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase

1997 • 225 citations

The role of inflammation after acute stroke

1998 • 204 citations

Functional subdivisions of the rat somatic sensorimotor cortex

1990 • 183 citations

Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats

1998 • 163 citations

Neuroprotective Effects of Inhibiting Poly(ADP-Ribose) Synthetase on Focal Cerebral Ischemia in Rats

1997 • 158 citations

Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia

1999 • 155 citations

Inhibition of Poly(ADP-Ribose) Polymerase

1998 • 125 citations

Enhanced Poly(ADP-ribosyl)ation after Focal Ischemia in Rat Brain

1998 • 113 citations

Alterations in Gait Following Ethanol Exposure During the Brain Growth Spurt in Rats

1990 • 99 citations

Impaired motor learning and diffuse axonal damage in motor and visual systems of the rat following traumatic brain injury

2001 • 69 citations

Correlation between behavioral status and cerebral glucose utilization in rats following freezing lesion

1986 • 51 citations

The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase

1999 • 37 citations

Amorphous calcium phosphate-mediated binding of matrix metalloproteinase-9 to fibrin is inhibited by pyrophosphate and bisphosphonate.

1998 • 26 citations

Stroke therapy : basic, preclinical, and clinical directions

1999 • 25 citations

STROKE THERAPY: BASIC, PRECLINICAL, AND CLINICAL DIRECTIONS.

2000 • 23 citations

Depletion of Nuclear Poly(ADP-ribose) Polymerase by Antisense RNA Expression: Influence on Genomic Stability, Chromatin Organization, DNA Repair, and DNA Replication

1996 • 20 citations

Cerebrovascular Diseases

1996 • 19 citations

Usual and Unusual Methods for Detection of Lipid Peroxides as Indicators of Tissue Injury in Cerebral Ischemia: What Is Appropriate and Useful?

1998 • 14 citations

Free Radical Scavengers and Spin Traps

1997 • 6 citations