Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 1,753 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Role of poly(ADP-ribose) formation in DNA repair

1992 • 1,142 citations

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1999 • 887 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

1963 • 613 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 597 citations

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

2000 • 532 citations

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1999 • 518 citations

Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.

1982 • 499 citations

Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis

1999 • 431 citations

Tankyrase promotes telomere elongation in human cells

2000 • 398 citations

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

1999 • 386 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis

1998 • 274 citations

Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles

2000 • 273 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

Characterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo

1987 • 237 citations

DNA repair and the role of chromatin structure

1991 • 218 citations

Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents

1989 • 218 citations

Protein-mediated nuclear export of RNA: 5S rRNA containing small RNPs in xenopus oocytes

1990 • 205 citations

Purification and Properties of a Glycohydrolase from Calf Thymus Splitting Ribose-Ribose Linkages of Poly(Adenosine Diphosphate Ribose)

1974 • 205 citations

Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase

1997 • 204 citations

ADP ribosylation of rat liver nucleosomal core histones.

1979 • 194 citations

NAD(+)-dependent repair of damaged DNA by human cell extracts.

1993 • 191 citations

Histone shuttling by poly ADP-ribosylation

1994 • 173 citations

Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase.

1981 • 173 citations

DNA Damage in the Nucleosome Core Is Refractory to Repair by Human Excision Nuclease

2000 • 172 citations

The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure

1989 • 168 citations

Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose).

1986 • 155 citations

Histone shuttling by poly(ADP-ribosylation).

1992 • 152 citations

Splitting of the Ribose-Ribose Linkage of Poly(Adenosine Diphosphate-Ribose) by a Calf Thymus Extract

1971 • 148 citations

A Human Poly(ADP-ribose) Polymerase Gene Family (ADPRTL): cDNA Cloning of Two Novel Poly(ADP-ribose) Polymerase Homologues

1999 • 145 citations

ATP for the DNA Ligation Step in Base Excision Repair Is Generated from Poly(ADP-ribose)

2000 • 140 citations

Poly(ADP-ribosylation) and apoptosis.

1999 • 139 citations

Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair

1992 • 135 citations

The Effect of poly(ADP-ribosyl)ation on Native and H1-depleted Chromatin

1989 • 134 citations

Review: Modulation of chromatin structure by poly(ADP-ribosyl)ation

1988 • 131 citations

Noncovalent interactions of poly(adenosine diphosphate ribose) with histones

1992 • 126 citations

Mode of action of poly(ADP-ribose) glycohydrolase

1994 • 125 citations

ADP-ribosyl protein lyase. Purification, properties, and identification of the product.

1984 • 123 citations

Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis

2001 • 116 citations

Inhibition of DNA polymerase α, DNA polymerase β, terminal deoxynucleotidyl transferase, and DNA ligase II by poly(ADP-ribosyl)ation reaction in vitro

1985 • 111 citations

Stimulation of poly(ADP-ribosyl)ation during Ehrlich ascites tumor cell "starvation" and suppression of concomitant DNA fragmentation by benzamide.

1983 • 96 citations

Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability

2001 • 90 citations

Characterization of sPARP-1

2000 • 79 citations

Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation.

1983 • 76 citations

Endoglycosidic cleavage of branched polymers by poly(ADP‐ribose) glycohydrolase

1994 • 76 citations

ADP-Ribosylation of Wild-Type p53in Vitro:Binding of p53 Protein to Specific p53 Consensus Sequence Prevents Its Modification

1996 • 75 citations

ADP-ribosylation of p53 tumor suppressor protein: Mutant but not wild-type p53 is modified

1996 • 75 citations

Accessing DNA damage in chromatin: Insights from transcription

1999 • 64 citations

ADP-ribosylation of ADPR-transferase and topoisomerase I in intact mouse epidermal cells JB6

1989 • 61 citations

Multiparametric Staining to Identify Apoptotic Human Cells

1997 • 61 citations

Poly(ADP-ribosylation) of histones in intact human keratinocytes

1989 • 53 citations

pADPRT‐2: a novel mammalian polymerizing(ADP‐ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans¹

1999 • 53 citations

Poly(ADP-ribosyl)ation of chromosomal proteins in the HeLa S3 cell cycle.

1982 • 51 citations

Site-specific repair of cyclobutane pyrimidine dimers in a positioned nucleosome by photolyase and T4 endonuclease V invitro

1998 • 50 citations

Cell cycle perturbations following DNA damage in the presence of ADP-ribosylation inhibitors

1985 • 50 citations

Role of (ADP-ribose)nCatabolism in DNA Repair

1997 • 49 citations

Preferential Perinuclear Localization of Poly(ADP-ribose) Glycohydrolase

1999 • 49 citations

Isolation and Cloning of Rat Poly(ADP-Ribose) Glycohydrolase: Presence of a Potential Nuclear Export Signal Conserved in Mammalian Orthologs

1999 • 48 citations

Isolation and purification of poly(ADP‐ribose) glycohydrolase from pig thymus

1983 • 46 citations

An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase

1990 • 46 citations

Purification of Poly(ADP-Ribose) Glycohydrolase and Detection of Its Isoforms by a Zymogram Following One- or Two-Dimensional Electrophoresis

1994 • 45 citations

Purification and properties of an (ADP-ribose)n glycohydrolase from guinea pig liver nuclei.

1986 • 43 citations

Evidence for two variants of poly(adenosine diphosphate ribose) glycohydrolase in rat testis

1976 • 41 citations

Therapeutic Applications of Apoptosis Research

2000 • 37 citations

Poly(ADP-ribose) Glycohydrolase Is Present and Active in Mammalian Cells as a 110-kDa Protein

1999 • 36 citations

Effect of hyperthermia on poly(adenosine diphosphate-ribose) glycohydrolase.

1988 • 36 citations

Biochemical properties and function of poly(ADP-ribose) glycohydrolase

1995 • 36 citations

Molecular heterogeneity and regulation of poly(ADP-ribose) glycohydrolase

1999 • 32 citations

Preferential degradation of protein-bound (ADP-ribose)n by nuclear poly(ADP-ribose) glycohydrolase from human placenta.

1993 • 32 citations

Reconstitution of an in vitro poly(ADP-ribose) turnover system

1990 • 31 citations

Purification and characterization of an (ADP‐ribose)n glycohydrolase from human erythrocytes

1990 • 31 citations

Poly(ADP-ribosyl)ation of DNA polymerase

1986 • 29 citations

Assignment<footref rid="foot01"><sup>1</sup></footref> of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization

1999 • 27 citations

Untitled

1999 • 26 citations

Mechanism of alteration of poly(adenosine diphosphate-ribose) metabolism by hyperthermia.

1988 • 25 citations

Comparison of ADP-ribosylation of chromosomal proteins between intact and broken cells

1985 • 18 citations

Chromosomal Mapping of the Tankyrase Gene in Human and Mouse

1999 • 13 citations

Properties of Poly(ADP-ribose) Glycohydrolase Purified from Pig Testis Nuclei

1996 • 12 citations

Change in activity of nuclear poly(ADP-ribose) glycohydrolase during the HeLa S3 cell cycle

1991 • 8 citations