The world according to PARP

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

Mammalian Telomeres End in a Large Duplex Loop

1999 • 2,372 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 1,753 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

1997 • 913 citations

Regulation of DNA-Dependent Activities by the Functional Motifs of the High-Mobility-Group Chromosomal Proteins

1999 • 837 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

1999 • 713 citations

ADP-RIBOSYLATION

1985 • 710 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

A Human Telomeric Protein

1995 • 689 citations

A Mammalian Telomerase-Associated Protein

1997 • 656 citations

The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition

2000 • 616 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 597 citations

Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins

1999 • 553 citations

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

2000 • 527 citations

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1999 • 518 citations

Telomeric localization of TRF2, a novel human telobox protein

1997 • 495 citations

The telomerase reverse transcriptase: components and regulation

1998 • 435 citations

Tankyrase promotes telomere elongation in human cells

2000 • 398 citations

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

1999 • 386 citations

TLP1: A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family

1997 • 379 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

High-Mobility Group Chromatin Proteins 1 and 2 Functionally Interact with Steroid Hormone Receptors To Enhance Their DNA Binding In Vitro and Transcriptional Activity in Mammalian Cells

1998 • 338 citations

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.

1993 • 327 citations

High mobility group protein-1 (HMG-1) is a unique activator of p53

1998 • 316 citations

Acetylation and chromosomal functions

2000 • 296 citations

Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers

1998 • 291 citations

ADP-Ribosylation of Proteins

1987 • 288 citations

Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles

2000 • 273 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

Vaults Are Up-regulated in Multidrug-resistant Cancer Cell Lines

1998 • 244 citations

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

1996 • 234 citations

HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation.

1996 • 230 citations

Mammalian telomeres and telomerase

2000 • 227 citations

High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.

1995 • 224 citations

Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex

1993 • 214 citations

The HMG-1 box protein family: classification and functional relationships

1995 • 209 citations

Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase

1997 • 204 citations

Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin

2000 • 202 citations

Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes

1999 • 201 citations

Inhibitor and NAD⁺ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling^,

1998 • 196 citations

The structure of a chromosomal high mobility group protein-DNA complex reveals sequence-neutral mechanisms important for non-sequence-specific DNA recognition

1999 • 193 citations

Ixr1, a Yeast Protein That Binds to Platinated DNA and Confers Sensitivity to Cisplatin

1993 • 177 citations

The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.

1994 • 174 citations

Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in HMG-1.

1979 • 154 citations

Vaults and Telomerase Share a Common Subunit, TEP1

1999 • 151 citations

TRF1 promotes parallel pairing of telomeric tracts in vitro

1998 • 146 citations

A Human Poly(ADP-ribose) Polymerase Gene Family (ADPRTL): cDNA Cloning of Two Novel Poly(ADP-ribose) Polymerase Homologues

1999 • 145 citations

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity.

1993 • 137 citations

Structure of the vault, a ubiquitous celular component

1999 • 129 citations

Unlocking vaults: organelles in search of a function

1991 • 128 citations

Higher plants possess two structurally different poly(ADP‐ribose) polymerases

1998 • 122 citations

Common features of the NAD‐binding and catalytic site of ADP‐ribosylating toxins

1994 • 111 citations

Interaction of Vault Particles with Estrogen Receptor in the MCF-7 Breast Cancer Cell

1998 • 108 citations

The specific interactions of HMG 1 and 2 with negatively supercoiled DNA are modulated by their acidic C-terminal domains and involve cysteine residues in their HMG 1/2 boxes

1993 • 107 citations

Characterization of a High Mobility Group 1/2 Homolog in Yeast

1996 • 104 citations

The binding motif recognized by HU on both nicked and cruciform DNA

1999 • 99 citations

Discovering new ADP-ribose polymer cycles: protecting the genome and more

1999 • 97 citations

HMG box proteins bind to four-way DNA junctions in their open conformation

1998 • 96 citations

Differences in the DNA‐Binding Properties of the Hmg‐Box Domains of HMG1 and the Sex‐Determining Factor SRY

1995 • 93 citations

Recognition of distorted DNA structures by HMG domains

2000 • 90 citations

Preferential Binding of High Mobility Group 1 Protein to UV-damaged DNA

1998 • 89 citations

Mechanism for Specificity by HMG-1 in Enhanceosome Assembly

2000 • 88 citations

High Mobility Group Protein 1 Interacts Specifically with the Core Domain of Human TATA Box-binding Protein and Interferes with Transcription Factor IIB within the Pre-initiation Complex

1999 • 87 citations

Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo

2000 • 84 citations

The acidic tail of the high mobility group protein HMG-D modulates the structural selectivity of DNA binding 1 1 Edited by M. Yaniv

1997 • 82 citations

RNA location and modeling of a WD40 repeat domain within the vault

2000 • 81 citations

Characterization of sPARP-1

2000 • 79 citations

Determinants of DNA Binding and Bending by theSaccharomyces cerevisiae High Mobility Group Protein NHP6A That Are Important for Its Biological Activities

1998 • 74 citations

Vaults are the answer, what is the question?

1996 • 73 citations

The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of proteins: insights from tail switching and tail removal

2000 • 70 citations

The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization

1993 • 64 citations

Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase

2000 • 63 citations

HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends

2000 • 54 citations

pADPRT‐2: a novel mammalian polymerizing(ADP‐ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans¹

1999 • 53 citations

The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.

2000 • 49 citations

The recognition of distorted DNA structures by HMG-D: a footprinting and molecular modelling study 1 1Edited by T. Richmond

1999 • 47 citations

A Role of Basic Residues and the Putative Intercalating Phenylalanine of the HMG-1 Box B in DNA Supercoiling and Binding to Four-way DNA Junctions

2000 • 46 citations

HMG1 and HU proteins: architectural elements in plant chromatin

1998 • 41 citations

Estrogen Treatment Induces Elevated Expression of HMG1 in MCF-7 Cells

1998 • 34 citations

HMG boxes of DSP1 protein interact with the Rel homology domain of transcription factors

2000 • 33 citations

Two Widely Spaced Initiator Binding Sites Create an HMG1-Dependent Parvovirus Rolling-Hairpin Replication Origin

2000 • 32 citations

High Mobility Group Proteins 1 and 2 Can Function as DNA-Binding Regulatory Components for DNA-Dependent Protein Kinase In Vitro

1998 • 31 citations

Structural Studies of the High Mobility Group Globular Domain and Basic Tail of HMG-D Bound to Disulfide Cross-Linked DNA

2000 • 27 citations

Alanine mutagenesis of high-mobility-group-protein-1 box B (HMG1-B)

2000 • 12 citations