Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex

Mitochondria and Apoptosis

1998 • 8,909 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

Caspases: killer proteases

1997 • 2,440 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Host factors and the pathogenesis of HIV-induced disease

1996 • 857 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

Fas Ligand-Induced Apoptosis

1999 • 778 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 • 659 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1999 • 544 citations

AIDS Retrovirus Induced Cytopathology: Giant Cell Formation and Involvement of CD4 antigen

1986 • 516 citations

Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis

1999 • 513 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

1998 • 454 citations

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

2000 • 449 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

1998 • 419 citations

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

1993 • 419 citations

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.

1995 • 386 citations

Multinucleated giant cells

2000 • 377 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1998 • 366 citations

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

1997 • 348 citations

In vivoHIV-1 infection of CD45RA⁺CD4⁺T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4⁺T cell decline

2000 • 259 citations

Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation

1999 • 248 citations

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

2000 • 239 citations

Apoptosis signaling in lymphocytes

1999 • 212 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4⁺T cells

1998 • 202 citations

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.

1996 • 195 citations

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

2000 • 177 citations

Apoptotic nuclear morphological change without DNA fragmentation

1999 • 158 citations

Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/murine heterokaryons

1992 • 147 citations

Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in fas-mediated hepatic apoptosis in mice

2000 • 134 citations

Susceptibility to infection by the human immunodeficiency virus (HIV) correlates with T4 expression in a parental monocytoid cell line and its subclones

1987 • 130 citations

HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4⁺T cells

2000 • 128 citations

Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells

1999 • 127 citations

Control of the Histone-Acetyltransferase Activity of Tip60 by the HIV-1 Transactivator Protein, Tat

1999 • 113 citations

Plasma membrane potential in thymocyte apoptosis.

1999 • 112 citations

Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions

1996 • 101 citations

Plasma Membrane Potential in Thymocyte Apoptosis

1999 • 97 citations

Programmed Cell Death as a Mechanism of CD4 and CD8 T Cell Deletion in AIDS: Molecular Control and Effect of Highly Active Anti‐retroviral Therapy

1999 • 91 citations

Acidic pH Promotes Dimerization of Bcl-2 Family Proteins

1998 • 87 citations

The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication

1997 • 85 citations

The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling

1999 • 82 citations

Apoptotic cell death upon contact of CD4+ T lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF receptor 1.

1997 • 79 citations

Impairment of T Cell Receptor-Dependent Stimulation in CD4+ Lymphocytes after Contact with Membrane-Bound HIV-1 Envelope Glycoprotein

1994 • 78 citations

Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis. Biochemical mechanisms

1999 • 76 citations

Human Immunodeficiency Virus Induces a Dual Regulation of Bcl-2, Resulting in Persistent Infection of CD4⁺T- or Monocytic Cell Lines

1998 • 74 citations

Both necrosis and apoptosis contribute to HIV-1-induced killing of CD4 cells

1999 • 70 citations

HIV-induced T cell syncytia are self-perpetuating and the primary cause of T cell death in culture.

1997 • 61 citations

A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis

1997 • 47 citations

bc1-2 expression facilitates human immunodeficiency virus type-1 mediated cytopathic effects during acute spreading infections

1996 • 39 citations

Inefficient Formation of a Complex among CXCR4, CD4 and gp120 in U937 Clones Resistant to X4 gp120–gp41-Mediated Fusion

2000 • 14 citations

The interactions of ferric and ferrous cytochrome c with cardiolipin in phospholipid membranes studied by solid-state 2H and 31P NMR

1998 • 11 citations

Fusion properties of cells constitutively expressing human parainfluenza virus type 4A haemagglutinin--neuraminidase and fusion glycoproteins

1994 • 7 citations