Inhibition of High K+-Induced Contraction by the ROCKs Inhibitor Y-27632 in Vascular Smooth Muscle: Possible Involvement of ROCKs in a Signal Transduction Pathway

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

2000 • 900 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

Calcium movements, distribution, and functions in smooth muscle.

1997 • 750 citations

An essential part for Rho–associated kinase in the transcellular invasion of tumor cells

1999 • 609 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase

1999 • 522 citations

Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2.

1988 • 298 citations

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

1996 • 280 citations

Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β

2000 • 273 citations

Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration

1999 • 260 citations

Ca2+ localization and sensitivity in vascular smooth muscle

1989 • 235 citations

Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle.

1992 • 214 citations

Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells

2000 • 210 citations

The effects of the Rho‐kinase inhibitor Y‐27632 on arachidonic acid‐, GTPγS‐, and phorbol ester‐induced Ca²⁺‐sensitization of smooth muscle

1998 • 199 citations

Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries

2000 • 199 citations

Inhibition of Rho‐associated kinase blocks agonist‐induced Ca²⁺ sensitization of myosin phosphorylation and force in guinea‐pig ileum

2000 • 186 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase

2002 • 165 citations

Inhibition of RhoA Translocation and Calcium Sensitization by In Vivo ADP-Ribosylation with the Chimeric Toxin DC3B

1997 • 151 citations

The Role of Actin Microfilaments in the Down-Regulation of the Degranulation Response in RBL-2H3 Mast Cells

1999 • 131 citations

Role of Rho proteins in carbachol‐induced contractions in intact and permeabilized guinea‐pig intestinal smooth muscle.

1996 • 111 citations

Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27

1998 • 95 citations

Effects of cGMP on [Ca2+]i, myosin light chain phosphorylation, and contraction in human myometrium

1991 • 91 citations

Carbachol-induced actin reorganization involves G_iactivation of Rho in human airway smooth muscle cells

1998 • 88 citations

Clostridium difficile toxin B inhibits carbachol‐induced force and myosin light chain phosphorylation in guinea‐pig smooth muscle: role of Rho proteins

1998 • 79 citations

[27] Purification of smooth muscle myosin light-chain kinase

1982 • 59 citations

Different effects of verapamil on cytosolic Ca2+ and contraction in norepinephrine-stimulated vascular smooth muscle.

1991 • 49 citations

Isolation of cDNA for Bovine Stomach 155 kDa Protein Exhibiting Myosin Light Chain Kinase Activity1

1992 • 49 citations

Regulatory mechanisms of calcium sensitization of contractile elements in smooth muscle

1998 • 43 citations

Actin-facilitated assembly of smooth muscle myosin induces formation of actomyosin fibrils

1992 • 39 citations

Effects of isoquinoline derivatives, HA1077 and H-7, on cytosolic Ca2+ level and contraction in vascular smooth muscle

1993 • 34 citations

Activation of Rho signaling contributes to lysophosphatidic acid-induced contraction of intact ileal smooth muscle of guinea-pig

2000 • 26 citations

Muscarinic stimulation does not induce rhoA/ROCK-mediated Ca 2+ sensitization of the contractile element in chicken gizzard smooth muscle

2000 • 21 citations

Increased contractility of rat uterine smooth muscle at the end of pregnancy

1998 • 21 citations

Isolation from Bovine Brain of 155 kDa Component Exhibiting Myosin Light Chain Kinase Activity1

1988 • 8 citations